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1: Forensic Sci Int. 1999 Oct 11;104(2-3):133-42.
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Age-related variation in the interstitial tissues of the cardiac conduction system; and autopsy study of 230 Han Chinese.

Song Y, Yao Q, Zhu J, Luo B, Liang S.

Department of Forensic Pathology, Sun Yat-sen University of Medical Sciences, Guangzhou, PR China.

The amount of fatty and fibrous tissues in 230 Han Chinese who died of noncardio-vascular diseases has been studied by a semi-quantitative method and analysed by chi-square test. The results have shown some consistency. Generally, in the sino-atrial node (SAN), fibrosis and fatty influtratin appear only after 40 years of age and increase one grade with every 20 years. The atrio-ventricular node (AVN) showed fatty change after 30 years of age and fibrosis appeared after 60. In the His bundle (HB), fatty infiltration and fibrosis appear after 40 years. The left bundle branch (LBB) showed similar changes. The appearance of fibrosis in the AVN seems to be later than that reported by Lev.

PMID: 10581719 [PubMed - indexed for MEDLINE]