Gross anatomic and histological comparison of uteri between PD-1-/- and WT mice. Gross anatomy of uteri between PD-1-/- and WT mice (129svEv-Brd background) at (A) 1 year and (B) 2 years of age, results showed that uteri from PD-1-/- mice in 2-year old are more larger than WT littermates. One of represents five mice was shown. (C) Gross anatomy of uteri from PD-1-/- and WT mice on Balb/c background at 2-year age was compared, results showed that uteri from PD-1-/- mice were similar to than from WT littermates. One of represents five mice was shown. Histology of uteri from WT (D) and PD-1-/- mice (E and F) in a 129svEv-Brd background at 2-year age was compared by using H&E staining. Star indicated glands and arrow showed neovascularization; D-F, Scale bar = 20 μm; N = 5 of each group.
Guo et al. Diagnostic Pathology 2014 9:97 doi:10.1186/1746-1596-9-97