Table 3

Meta-analysis of the XPC polymorphisms and gastric cancer risk
Comparison Population No. of studies Test of association Mode Test of heterogeneity
OR 95% CI P Value χ2 PQ Value I2
Lys939Gln
Gln/Gln vs. Lys/lys Overall 5 1.123 0.881-1.431 0.349 F 2.69 0.612 0.0
Caucasian 2 1.016 0.490-2.109 0.965 F 2.31 0.128 46.8
Asian 3 1.140 0.857-1.516 0.368 F 0.34 0.843 0.0
PB 2 1.260 0.877-1.810 0.212 F 0.24 0.623 0.0
HB 3 1.026 0.741-1.420 0.879 F 1.76 0.414 0.0
High quality 3 1.179 0.860-1.616 0.308 F 0.75 0.686 0.0
Low quality 2 1.048 0.718-1.530 0.807 F 1.71 0.191 41.6
Gln/Lys vs. Lys/lys Overall 5 1.083 0.917-1.277 0.347 F 1.21 0.876 0.0
Caucasian 2 0.993 0.689-1.432 0.972 F 0.87 0.352 0.0
Asian 3 1.107 0.919-1.332 0.284 F 0.08 0.962 0.0
PB 2 1.026 0.795-1.324 0.846 F 0.64 0.424 0.0
HB 3 1.126 0.906-1.400 0.285 F 0.27 0.872 0.0
High quality 3 1.062 0.855-1.319 0.587 F 0.90 0.639 0.0
Low quality 2 1.112 0.861-1.437 0.417 F 0.24 0.628 0.0
Gln/Gln + Gln/Lys vs. Lys/lys Overall 5 1.092 0.933-1.277 0.273 F 0.24 0.994 0.0
Caucasian 2 1.015 0.720-1.430 0.933 F 0.01 0.906 0.0
Asian 3 1.113 0.933-1.327 0.235 F 0.00 0.998 0.0
PB 2 1.076 0.846-1.369 0.551 F 0.18 0.667 0.0
HB 3 1.103 0.897-1.356 0.351 F 0.03 0.986 0.0
High quality 3 1.087 0.886-1.333 0.424 F 0.21 0.900 0.0
Low quality 2 1.098 0.860-1.401 0.453 F 0.02 0.881 0.0
Gln/Gln vs. Gln/Lys + Lys/lys Overall 5 1.046 0.838-1.307 0.691 F 6.57 0.160 39.2
Caucasian 2 0.921 0.344-2.468 0.870 F 5.98 0.114 43.3
Asian 3 1.083 0.829-1.417 0.558 F 0.47 0.791 0.0
PB 2 1.253 0.896-1.751 0.187 F 0.77 0.381 0.0
HB 3 0.914 0.680-1.229 0.552 F 3.90 0.142 48.8
High quality 3 1.157 0.862-1.553 0.331 F 1.66 0.435 0.0
Low quality 2 0.828 0.400-1.712 0.610 F 3.90 0.148 44.3
Ala499Val
Val/Val vs. Ala/Ala Asian 3 0.861 0.632-1.172 0.341 F 0.57 0.754 0.0
Val/Ala vs. Ala/Ala Asian 3 0.815 0.611-1.089 0.167 F 4.72 0.194 37.6
Val/Val + Val/Ala vs. Ala/Ala Asian 3 0.823 0.630-1.076 0.155 F 4.49 0.106 35.5
Val/Val vs. Val/Ala + Ala/Ala Asian 3 0.947 0.703-1.274 0.717 F 0.04 0.981 0.0
PAT−/+
+/+vs. −/− Overall 2 1.035 0.763-1.404 0.825 F 0.12 0.726 0.0
+/− vs. −/− Overall 2 0.855 0.681-1.073 0.176 F 0.00 0.975 0.0
(+/+) + (+/−) vs. (−/−) Overall 2 0.896 0.724-1.111 0.317 F 0.05 0.830 0.0
(+/+) vs. (+/−) + (−/−) Overall 2 1.141 0.871-1.495 0.338 F 0.20 0.652 0.0

OR, odds ratio; CI, confidence intervals; R, random effects model; F, fixed effects model; PB, Population–based; HB, Hospital–based.

Peng et al.

Peng et al. Diagnostic Pathology 2014 9:96   doi:10.1186/1746-1596-9-96

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