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Primary extranodal NK/T cell lymphoma, nasal-type of uterus with adenomyosis: a case report

Jian-chen Fang*, Jue Zhou, Zheng Li and Zhao-xia Xia

Author Affiliations

Ningbo Diagnostic Pathology Center, Ningbo 315031, China

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Diagnostic Pathology 2014, 9:95  doi:10.1186/1746-1596-9-95

Published: 23 May 2014


Natural killer (NK)/T cell lymphoma of the female genital tract is extremely rare. We here report a case of ‘nasal type’ NK/T cell lymphoma arising in the uterus with adenomyosis in a 41-year-old woman with fever and hypogastralgia. The histologic analysis demonstrated a highly aggressive tumor with characteristic angiocentric/angiodestructive growth pattern and focal necrosis. The lymphoma cells displayed a CD3ϵ/CD56/TIA-1/granzyme-B/Perforin-positive and CD20/CD79a/CD4/CD8-negative immunophenotype and positive for Epstein-Barr virus by EBER in situ hybridization. Clinically, the disease was limited to the uterus at the initial diagnosis, but progressed rapidly. The patient died on day 54 after hysterectomy, irrespective of intensive chemotherapy.

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Uterus; NK/T cell lymphoma; Extranasal type