Table 5

Unadjusted and adjusted hazard ratios for death within 5 years in relation to re-evaluated histopathology parameters
n (events) Unadjusted HR (95% CI) p-value Adjusted HR (95% CI) p-value
Age, continuous 172 (112) 1.0 (1.0-1.0) 0.479 1.0 (1.0-1.1) 0.015
Sex
 Female 86 (47)
 Male 86 (65) 1.5 (1.0-2.2) 0.042 1.4 (0.9-2.0) 0.131
T-stage
 T1 8 (3)
 T2 23 (12) 1.5 (0.4-5.2) 0.553 1.1 (0.3-4.4) 0.847
 T3 102 (66) 2.7 (0.8-8.6) 0.995 1.0 (0.3-3.8) 0.948
 T4 39 (31) 3.4 (1.0-11.2) 0.043 1.3 (0.3-5.1) 0.683
N-stage
 N0 67 (37)
 N1-N2 105 (75) 2.0 (1.3-2.9) 0.001 1.3 (0.8-2.0) 0.265
Tumour size, continuous 172 (112) 1.0 (1.0-1.0) 0.010 1.0 (1.0-1.0) 0.533
Tumour differentiation
 Well-moderate 73 (38)
 Poor 99 (74) 2.3 (1.5-3.3) <0.001 1.9 (1.2-2.8) 0.002
Tumour morphology
 Intestinal type 63 (31)
 Pancreatobiliary type 109 (81) 2.3 (1.5-3.4) <0.001 1.3 (0.7-2.3) 0.394
Margins
 R0 25 (7)
 R1-Rx 147 (105) 3.3 (1.5-7.0) 0.002 2.2 (1.0-4.9) 0.046
Perineural growth
 No 68 (33)
 Yes 104 (79) 2.4 (1.6-3.7) <0.001 1.1 (0.6-1.8) 0.779
Growth in lymphatic vessels
 No 63 (30)
 Yes 109 (82) 2.2 (1.4-3.3) <0.001 1.2 (0.8-1.9) 0.420
Growth in blood vessels
 No 131 (74)
 Yes 41 (38) 3.1 (2.1-4.7) <0.001 2.4 (1.6-3.7) <0.001
Growth in peripancreatic fat
 No 67 (30)
 Yes 105 (82) 2.8 (1.8-4.3) <0.001 2.1 (1.4-3.3) 0.001

HR, hazard ratio. CI, confidence interval. Bold text indicates p < 0.05.

Elebro and Jirström

Elebro and Jirström Diagnostic Pathology 2014 9:80   doi:10.1186/1746-1596-9-80

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