Table 4

Five year overall survival in relation to margin status in the original reports and after re-evaluation
Margin status in original reports Margin status after re-evaluation
Number Median OS (IQR) Unadjusted HR (95% CI) Adjusted HR (95% CI) Number Median OS (IQR) Unadjusted HR (95% CI) Adjusted HR (95% CI)
R0 90 36.3 (23.1 - n.r.) 25 n.r. (35.0 - n.r.)
Rx 54 40.2 (24.0 - n.r.) 2.3 (1.0 - 5.2) 2.2 (1.0 - 4.9)
R1 69 25.1 (14.0 - 46.3) 1.6 (1.1 - 2.4) 1.0 (0.7 - 1.6) 93 25.4 (14.6 - 41.6) 3.3 (1.5 - 7.0)

Hazard ratios (HR) for risk of death within 5 years in relation to margin status, with R0 as reference. OS in the re-evaluated R0-group was significantly better than in the original report R0-group (p < 0.001). Differences in OS between the three levels of margin status in the re-evaluated material were significant; R0 vs R1 (p < 0.001), R1 vs Rx (p = 0.005) and R0 vs Rx (p = 0.043). HR for both original report and re-evaluated margin status adjusted for re-evaluated parameters.

R0, uninvolved margins. Rx, uncertain margin status. R1, cancer less than 1 mm from margin. IQR, interquartile range. CI, confidence interval. N.r., not reached.

Elebro and Jirström

Elebro and Jirström Diagnostic Pathology 2014 9:80   doi:10.1186/1746-1596-9-80

Open Data