|Five year overall survival in relation to margin status in the original reports and after re-evaluation|
|Margin status in original reports||Margin status after re-evaluation|
|Number||Median OS (IQR)||Unadjusted HR (95% CI)||Adjusted HR (95% CI)||Number||Median OS (IQR)||Unadjusted HR (95% CI)||Adjusted HR (95% CI)|
|R0||90||36.3 (23.1 - n.r.)||25||n.r. (35.0 - n.r.)|
|Rx||54||40.2 (24.0 - n.r.)||2.3 (1.0 - 5.2)||2.2 (1.0 - 4.9)|
|R1||69||25.1 (14.0 - 46.3)||1.6 (1.1 - 2.4)||1.0 (0.7 - 1.6)||93||25.4 (14.6 - 41.6)||3.3 (1.5 - 7.0)|
Hazard ratios (HR) for risk of death within 5 years in relation to margin status, with R0 as reference. OS in the re-evaluated R0-group was significantly better than in the original report R0-group (p < 0.001). Differences in OS between the three levels of margin status in the re-evaluated material were significant; R0 vs R1 (p < 0.001), R1 vs Rx (p = 0.005) and R0 vs Rx (p = 0.043). HR for both original report and re-evaluated margin status adjusted for re-evaluated parameters.
R0, uninvolved margins. Rx, uncertain margin status. R1, cancer less than 1 mm from margin. IQR, interquartile range. CI, confidence interval. N.r., not reached.
Elebro and Jirström
Elebro and Jirström Diagnostic Pathology 2014 9:80 doi:10.1186/1746-1596-9-80