Table 1

Standardized vs non-standardized protocol: Characteristics of 175 re-evaluated periampullary adenocarcinomas
NSP SP p-value All
(n = 129) (n = 46) (n = 175)
Tumour origin 0.040
 Duodenum 9 (7%) 5 (11%) 14 (8%)
 Ampulla, both types 58 (45%) 12 (26%) 70 (40%)
 Distal Bile Duct 27 (21%) 18 (39%) 45 (26%)
 Pancreas 35 (27%) 11 (24%) 46 (26%)
Tumour size, mm
 M (IQR) 30 (20–35) 30 (25–40) 0.649 30 (21–35)
 Larger than 20 mm 92 (71%) 42 (91%) 0.008 134 (77%)
Differentiation, poor 70 (54%) 31 (67%) 0.164 101 (58%)
Lymph nodes
 In PD specimen, M (IQR) 6 (3–10) 9 (7–13) 0.102 7 (4–10)
 From PD specimens, M (IQR) 1 (0–2) 7 (3–9) <0.001 2 (0–5)
 Total PD specimen, M (IQR) 8 (5–12) 16 (12–19) <0.001 11 (6–15)
 ≥10 lymph nodes PD specimen, n (%) 58 (45%) 40 (87%) <0.001 98 (56%)
 Other local lymph nodes, M (IQR) 0 (0–1) 0 (0–1) 0.400 0 (0–1)
 Total, all lymph nodes, M (IQR) 9 (5–13) 16 (13–20) <0.001 11 (6–16)
Involved lymph nodes
 In PD specimen, M (IQR) 1 (0–2) 3 (0–4) 0.001 1 (0–3)
 From PD specimen, M (IQR) 0 (0–0) 0 (0–1) 0.024 0 (0–0)
 Total PD specimen, M (IQR) 1 (0–2) 3 (0–4) 0.023 1 (0–3)
 Other local, M (IQR) 0 (0–0) 0 (0–0) 0.017 0 (0–0)
 Total, all involved lymph nodes, M (IQR) 1 (0–2) 3 (0–4) 0.015 1 (0–3)
 N-stage, pN1 (for duodenum pN1-N2) 74 (57%) 33 (72%) 0.113 107 (61%)
Margin involvement <0.001
 R1 60 (47%) 34 (74%) 94 (54%)
 Rx (uncertain/unassessable) 56 (43%) 0 (0%) 56 (32%)
 R0 13 (10%) 12 (26%) 25 (14%)
Perineural infiltration 71 (55%) 34 (74%) 0.035 105 (60%)
Infiltration in lymph vessels 79 (61%) 32 (70%) 0.374 111 (63%)
Infiltration in blood vessels 38 (29%) 4 (9%) 0.004 42 (24%)
Infiltration in peripancreatic fat 71 (55%) 36 (78%) 0.008 107 (61%)
T-stage 0.074
 pT1 8 (6%) 0 (0%) 8 (4%)
 pT2 21 (17%) 3 (6%) 24 (14%)
 pT3 70 (54%) 33 (72%) 103 (59%)
 pT4 30 (23%) 10 (22%) 40 (23%)
Blocks from PD-specimen
 Regular blocks, Median (IQR) 15 (12–22) 23 (20–27) 0.001
 Mean (min - max) 17 (6–48) 24 (14–36)
 Large blocks, Median (IQR) 0 (0–2) 0 (0–0) <0.001
 Mean (min - max) 1 (0–8) 0 (0–0)

SP, standardized procedure. NSP, non-standardized procedure. PD, pancreatoduodenectomy. M, median. IQR, interquartile range. SMA, superior mesenteric artery. SMV, superior mesenteric vein. For margin involvement p-values were calculated R1 vs R0 and Rx. Bold text indicates p < 0.05.

Elebro and Jirström

Elebro and Jirström Diagnostic Pathology 2014 9:80   doi:10.1186/1746-1596-9-80

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