Postoperative photomicrographs of lesion in MEC component. (a) The tumor was composed of nests of epidermoid cells with mucin-producing areas (left side of the figure) and lymphocyte-rich areas (right side of figure). They represented the MEC component and thymoma component, respectively. (b) High magnification showed the mucin-producing cells were surrounded by epidermoid cells in MEC component. (c) Invasive nests of well-differentiated epidermoid cells, mucin-producing and intermediate cells were observed in MEC areas. Bands of fibrous connective tissue were observed in the tumor. (d) The epidermoid cells were observed to be positive for CK5/6, but the mucin-producing cells were CK5/6-negative. (e) MEC component was negative for CD5. (f) The Alcian blue-positive material was seen in lumen of gland structure and the mucin-producing cells within the nest of epidermoid cells. (a, H & E staining with original magnification of 200 ×; b-c, H & E staining with original magnification of 400 ×; d-e, immunohistochemical staining with original magnification of 400 ×; f, Alcian blue staining with original magnification × 400).
Wu et al. Diagnostic Pathology 2014 9:8 doi:10.1186/1746-1596-9-8