Table 2

Cox proportional hazards analysis of colorectal cancer specific survival according to HMG-CoA reductase expression
Full cohort Stage I-II disease Stage I-II disease
HR (95%CI) n (events) HR (95%CI) n (events) HR (95%CI) n (events)
Unadjusted Unadjusted Unadjusted
HMGCR pos 1.00 474 (153) 1,00 243 (33) 1,00 208 (116)
HMGCR neg 1.79 (1-20-2.66) 61 (29) 1.56 (0.61-4.01) 25 (5) 1.71 (1.09-2.68) 31 (23)
Adjusted Adjusted Adjusted
HMGCR pos 1.00 406 (126) 1.00 227 (30) 1.00 179 (96)
HMGCR neg 0.85 (0.51-1.41) 45 (19) 1.23 (0.41-3.70) 23 (4) 0.82 (0.46-1.46) 22 (15)

Multivariable analysis included adjustment for age (continuous), T-stage (1-2, 3, 4), sex, N-stage (0,1,2), M-stage, differentiation grade (high-intermediate vs. low), vascular invasion (no, yes, unknown) and MSI screening status.

Bengtsson et al.

Bengtsson et al. Diagnostic Pathology 2014 9:78   doi:10.1186/1746-1596-9-78

Open Data