Table 3

Meta-analysis of the TNF-α gene polymorphisms on prostate cancer risk
Comparison Population No. of studies Test of association Test of heterogeneity
OR 95% CI P value model X2 I2(%) P value
TNF-α-308G/A
AA vs. GG Overall 14 0.936 0.733-1.195 0.595 F 16.20 19.8 0.238
Caucasia 8 0.762 0.569-1.021 0.068 F 5.68 0.0 0.461
Asia 3 1.558 0.620-3.419 0.346 F 4.29 30.1 0.231
Mix 2 1.616 0.917-2.848 0.097 F 0.11 0.0 0.736
African-American 1 1.119 0.181-6.903 0.904 - - - -
PB 5 0.886 0.660-1.190 0.422 F 6.72 40.5 0.152
HB 7 0.924 0.557-1.481 0.743 F 6.76 11.2 0.344
HV 2 2.861 0.732-11.181 0.131 F 0.00 0.0 0.979
AG vs. GG Overall 14 1.105 0.932-1.309 0.251 R 41.38 68.6 <0.001
Caucasia 7 1.234 0.965-1.600 0.092 R 31.63 81.0 <0.001
Asia 4 0.928 0.699-1.234 0.608 F 4.12 27.2 0.249
Mix 2 1.065 0.882-1.288 0.512 F 0.70 0.0 0.404
African-American 1 0.458 0.204-1.027 0.058 - - - -
PB 5 0.997 0.899-1.106 0.958 F 3.39 0.0 0.495
HB 7 1.174 0.709-1.746 0.428 R 32.78 81.7 <0.001
HV 2 1.477 1.047-2.085 0.026 F 0.27 0.0 0.602
AA + AG vs. GG Overall 14 1.103 0.932-1.306 0.254 R 43.71 70.3 <0.001
Caucasia 8 1.206 0.941-1.545 0.138 R 32.21 81.4 <0.001
Asia 3 1.008 0.657-1.547 0.97 R 6.83 56.1 0.078
Mix 2 1.101 0.916-1.323 0.304 F 0.63 0.0 0.429
African-American 1 0.513 0.242-1.088 0.082 - - - -
PB 5 0.987 0.892-1.091 0.799 F 4.96 19.4 0.291
HB 7 1.174 0.803-1.719 0.408 R 32.22 81.4 <0.001
HV 2 1.531 1.093-2.145 0.013 F 0.24 0.0 0.628
AA vs. GG + AG Overall 14 0.92 0.721-1.172 0.502 F 16.2 19.7 0.239
Caucasia 7 0.748 0.559-1.001 0.051 F 5.93 0.0 0.431
Asia 4 1.559 0.618-3.935 0.347 F 3.98 24.7 0.263
Mix 2 1.569 0.893-2.757 0.117 F 0.19 0.0 0.660
African-American 1 1.303 0.212-7.991 0.775 - - - -
PB 5 0.883 0.659-1.184 0.407 F 6.26 36.1 0.181
HB 7 0.886 0.555-1.413 0.611 F 7.49 19.9 0.278
HV 2 2.65 0.679-10.341 0.161 F 0.00 0.0 0.997
TNF-α-238G/A
AA vs. GG Overall 4 1.09 0.403-2.943 0.866 F 4.61 34.9 0.203
Caucasia 3 1.29 0.436-3.816 0.645 F 4.35 54.1 0.113
African-American 1 0.391 0.018-8.288 0.547 - - - -
HB 3 1.579 0.492-5.071 0.442 F 3.750 46.7 0.153
PB 1 0.344 0.036-3.310 0.355 - - - -
AG vs. GG Overall 5 1.07 0.680-1.683 0.77 R 12.49 68.0 0.014
Caucasia 3 1.284 0.841-2.025 0.282 R 5.99 66.6 0.050
Asia 1 0.431 0.200-0.931 0.032 - - - -
African-American 1 1.179 0.408-3.405 0.706 - - - -
HB 4 1.008 0.506-2.010 0.981 R 11.3 73.4 0.01
PB 1 1.248 0.944-1.649 0.12 - - - -
AA + AG vs. GG Overall 5 1.06 0.713-1.575 0.774 R 9.95 59.8 0.041
Caucasia 3 1.226 0.982-1.531 0.072 F 3.33 39.9 0.189
Asia 1 0.431 0.200-0.931 0.032 - - - -
African-American 1 0.983 0.351-2.752 0.974 - - - -
HB 4 0.984 0.535-1.808 0.958 R 9.170 67.3 0.027
PB 1 1.221 0.926-1.610 0.156 - - - -
AA vs. GG + AG Overall 4 1.036 0.388-2.767 0.943 F 4.9 38.2 0.182
Caucasia 3 0.892 0.084-9.494 0.925 R 4.63 56.8 0.099
African-American 1 0.386 0.018-8.161 0.541 - - - -
HB 3 1.468 0.467-4.615 0.511 F 4.050 50.6 0.132
PB 1 0.336 0.035-3.238 0.346 - - - -

Ma et al.

Ma et al. Diagnostic Pathology 2014 9:74   doi:10.1186/1746-1596-9-74

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