Table 2

Allelic and genotypic associations between three selected SNPs and AMD
SNP information Allelic associations Genotypic associations
dbSNP ID Gene chr:pos Location Allelesa Effective allele frequency P valueb Genotypic distributions P valuec P valued
OR (95% CI) OR (95% CI) OR (95% CI)
rs2842992 SOD2 6:160071159 Intergenic A/G Case 0.523 GA case 0.547 0.277 AA/AG/GG Case 47/107/38 0.266 0.661
Control 0.558 Non-GA case 0.508 0.87 (0.67-1.13) Control 109/165/69 0.87 (0.67-1.12) 0.93 (0.68-1.28)
rs1789110 MBP 18:74859044 Intergenic A/C Case 0.542 GA case 0.533 0.850 AA/AC/CC Case 55/107/38 0.798 0.537
Control 0.535 Non-GA case 0.548 1.03 (0.80-1.33) Control 100/171/76 1.03 (0.80-1.33) 1.10 (0.81-1.51)
rs722782 C80rf42 8:516479 Intergenic A/C Case 0.473 GA case 0.471 0.281 AA/AC/CC Case 43/92/53 0.279 0.080
Control 0.508 Non-GA case 0.475 0.87 (0.67-1.12) Control 97/177/91 0.87 (0.68-1.12) 0.76 (0.56-1.03)

Abbreviations: chr:pos chromosome:position, OR odds ratio, CI confidence interval.

aEffective alleles are indicated in bold type, and odds ratios were calculated based on this allele.

bORs, 95% CIs and P values were calculated based on Fisher’s exact test.

cORs, 95% CIs and P values were calculated using logistic regression, assuming the additive model.

dORs, 95% CIs and P values were calculated using logistic regression, assuming the additive model with adjustment for age.

Kan et al.

Kan et al. Diagnostic Pathology 2014 9:73   doi:10.1186/1746-1596-9-73

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