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Open Access Letter to the Editor

Association study of newly identified age-related macular degeneration susceptible loci SOD2, MBP, and C8orf42 in Han Chinese population

Mengyuan Kan1, Fatao Liu1, Xiaoling Weng2, Junyi Ye2, Ting Wang1, Mingqing Xu3, Lin He123* and Yun Liu2*

Author Affiliations

1 Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, Shanghai 200031, P. R. China

2 Institutes of Biomedical Sciences, Fudan University, Ming Dao Building, 138 Yi Xue Yuan Road, Shanghai 200032, P. R. China

3 Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai 200030, P.R. China

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Diagnostic Pathology 2014, 9:73  doi:10.1186/1746-1596-9-73

Published: 25 March 2014

Abstract

A recent genome-wide association study has reported three newly identified susceptible loci (rs2842992 near the gene SOD2, rs1789110 near the gene MBP and rs722782 near the gene C8orf42) to be associated with the geographic atrophy subtype of age-related macular degeneration in European-descent population. We investigated the correlation between these variants and advanced age-related macular degeneration for the first time in a Han Chinese cohort; however, no evidence supports these previously identified loci contribute to advanced age-related macular degeneration susceptibility in Chinese population.

Keywords:
Age-related macular degeneration; Han Chinese population; Association study