Immunohistochemical staining for TP53,MDMx and MDM2 in primary breast cancer. (A) p53 accumulation with diffuse strong nuclear staining in the tumor cells (×400). (B) MDMx overexpression with diffuse and strong nuclear staining (×400) in the tumor cells with Mdmx amplification. (C) MDM2 overexpression with nuclear and cytoplasmic staining in the tumor cells (×400).
Yu et al. Diagnostic Pathology 2014 9:71 doi:10.1186/1746-1596-9-71