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Clinicopathological and EBV analysis of respiratory epithelial adenomatoid hamartoma

Xing Hua1, Xiaoxiao Huang1, Zexiao Liao1, Qi Xian1 and Lina Yu23*

Author Affiliations

1 Department of Pathology, The Forth Affiliated Hospital of Jinan University, 396# Tong Fu Zhong Rd, Guangzhou 510515, China

2 Department of Pathology, Nanfang Hospital, Southern Medical University, 510515 Tonghe, Guangzhou, People’s Republic of China

3 Department of Pathology, College of Basic Medicine, Southern Medical University, 510515 Tonghe, Guangzhou, People’s Republic of China

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Diagnostic Pathology 2014, 9:70  doi:10.1186/1746-1596-9-70

Published: 25 March 2014



To investigate the clinicopathological characteristics of respiratory epithelial adenomatoid hamartoma (REAH) in residents of Southern China and to study the correlation between REAH and Epstein-Barr virus (EBV).


Clinicopathological data of 53 cases of REAH were retrospectively analyzed. The immunoreactivity for CK 7, CK20, CEA, p53, and Ki-67, Alcian blue–periodic acid-Schiff (AB-PAS) staining and in situ hybridization for EBV-encoded RNA (EBER) were carried out.


REAH lesions were covered with ciliated columnar epithelium and proliferation of subepithelial glands, which were positive for CK7, and negative for CK20, CEA, and p53. Goblet cell metaplasia was stained blue by AB-PAS. The frequency of EBER positive cases in REAH located in nasopharynx was 27.78%, compared with that in the nasal cavity (15.79%) and paranasal sinuses (12.50%), there were no statistical differences.


REAH is an uncommon entity with distinctive morphologic features and EBV may have nothing to do with REAH.

Virtual slides

The virtual slide(s) for this article can be found here: webcite

Respiratory epithelial adenomatoid hamartoma; Nasopharynx; Sinonasal tract; Epstein-Barr virus