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Open Access Research

Expression of Tiam1 predicts lymph node metastasis and poor survival of lung adenocarcinoma patients

Shuguang Liu12, Yumei Li12, Wenjuan Qi12, Yunfei Zhao12, Aili Huang12, Wenjie Sheng12, Bin Lei12, Peixin Lin12, Haili Zhu12, Wenxia Li12 and Hong Shen12*

Author Affiliations

1 Department of Pathology, Nanfang Hospital, Southern Medical University, 510515 Tonghe, Guangzhou, People’s Republic of China

2 Department of Pathology, School of Basic Medical Sciences, Southern Medical University, 510515 Tonghe, Guangzhou, People’s Republic of China

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Diagnostic Pathology 2014, 9:69  doi:10.1186/1746-1596-9-69

Published: 24 March 2014

Abstract

Background

To assess the value of Tiam1 in predicting lymph node metastasis and survival after curative resection in patients with lung adenocarcinoma.

Methods

Immunohistochemical staining for Tiam1 was performed on 98 adenocarcinoma and 30 normal lung tissues. The association of Tiam1 protein expression with the clinicopathological characteristics and the prognosis of lung adenocarcinoma were subsequently assessed.

Results

Immunohistochemical analysis showed that 60 of 98 (61.22%) adenocarcinoma tissues showed high expression of Tiam1, and high Tiam1 expression was significantly associated with advanced TNM stage (P < 0.0005) and lymph node status (P < 0.0005) of lung adenocarcinoma. Moreover, the lung adenocarcinoma patients with low Tiam1 expression had higher overall survival than patients with high Tiam1 expression (log rank value = 10.805, P = 0.001). High expression of Tiam1 predicted poor overall survival of patients in stages I + II (P = 0.006). Furthermore, multivariate analysis indicated that high expression of Tiam1 protein was an independent prognostic factor for overall survival (P = 0.011) in patients with lung adenocarcinoma.

Conclusion

These findings suggest for the first time that Tiam1 expression may be beneficial in predicting lymph node metastasis and survival of patients with lung adenocarcinoma. A future study will investigate whether Tiam1 can serve as a novel therapeutic target in lung adenocarcinoma.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1377798917111123 webcite.

Keywords:
Lung adenocarcinoma; Lymph node metastases; Immunohistochemistry; Tiam1