A549 cell xenograft tumor for detecting myricetin sensitizing tumors to irradiation in vivo. A549 cells were implanted subcutaneously in immunodeficient female BALB/C nude mice. Mice treated with myricetin alone (20 mg/kg, once daily for 14 days) or myricetin plus radiotherapy (myricetin was given 1 h before IR) at 2-Gy fractions for a total dose of 20 Gy. Shown are medium tumor volume of each group as function of time after implantation. The data curve showed that radiotherapy combine with myricetin could inhibit the tumor growth significantly, compared with other three groups.
Zhang et al. Diagnostic Pathology 2014 9:68 doi:10.1186/1746-1596-9-68