Radiosensitizing effect of myricetin on tumor cells apoptosis. (A) Myricetin increase the radiosensitivity of apoptosis rate in A549 and H1299 cells. The cells were stained by annexin V-FITC/PI, and cell apoptosis was analyzed by FCM. The data showed that apoptotic cells was statistically significant increased (*P < 0.05) in radiotherapy + myricetin combination group, compared to other three groups. (B) Western blot for Caspase-3 expression in control (c), myricetin-alone (M), radiotherapy-alone (R) and radiotherapy + myricetin combination (M + R) group. (C) Myricetin increase the Caspase-3 expression in occurred for radiotherapy in A549 and H1299 cells. The data aslo showed higher expression of Caspase-3 (*P < 0.05) in radiotherapy + myricetin combination group, compared to other three groups. Data are presented as the mean of triplicate experiments.
Zhang et al. Diagnostic Pathology 2014 9:68 doi:10.1186/1746-1596-9-68