Myricetin radiosensitizes cancer cells in vitro. (A) and (B) Myricetin alone on clonogenic survival in A549 and H1299 cells lines. Cells were treated with indicated doses of myricetin for 24 h and colony formation assays were conducted. Compared to the control, there was little effect on clonogenic survival treated with different doses myricetin (P < 0.05). (C) Radiosensitivity was measured by colony formation assay in the human lung cancer cell line A549 treated with control or 25 μM of myricetin (1 h before IR and maintained for 24 h), Compared to the control, clonogenic survival of A549 cells treated with myricetin were decreased significantly under different irradiation doses. (D) Radiosensitivity of the human lung cancer cell line H1299. Shown are averages of triplicate samples. Standard errors are shown by error bars.
Zhang et al. Diagnostic Pathology 2014 9:68 doi:10.1186/1746-1596-9-68