A case report of seronegative cat scratch disease, emphasizing the histopathologic point of view
1 Department of Hospital Pathology, Uijeongbu St. Mary’s Hospital College of Medicine, The Catholic University of Korea 271, Cheonbo-ro, Uijeongbu-si, Gyenggi-do 480-717, Republic of Korea
2 Department of Internal Medicine, The Catholic University of Korea, College of Medicine, Seoul, Korea
3 Department of Laboratory Medicine, Inje University Sanggye Paik Hospital, Seoul, Korea
4 Division of Zoonoses (CJD/Rabies/LB), Center for Immunology & Pathology, National Institute of Health (Korea CDC), Seoul, Korea
Diagnostic Pathology 2014, 9:62 doi:10.1186/1746-1596-9-62Published: 19 March 2014
Cat scratch disease, necrotizing granulomatous lymphadenitis caused by Bartonella henselae, usually benign and self-limited. However, various clinical manifestations and no pathognomonic histopathologic features can lead to misinterpretations and diagnostic disputes. We report a case of cat scratch disease in a 39-yr-old male patient with fever and left axillary lymphadenitis. He had a history of cat bite on the left hand dorsum. On excision, the lymph node showed follicular hyperplasia, stellate microabscesses with a rim of granulomatous inflammation. Warthin-Starry silver staining showed many clumps of silver-stained bacilli within the necrotic foci. Serological tests were negative. Diagnosis was established by PCR analysis.
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