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Low-grade myxofibrosarcoma following a metal implantation in femur: a case report

Weisong Li12, Dan Li3*, Xiansen Zhu1, Shaohui Lu4, Chunlei He5 and Qingchun Yang1*

Author Affiliations

1 Department of Pathology, Gannan Medical University, No. 1, Yixueyuan Road, Ganzhou, Jiangxi 341000, China

2 Department of Pathology, the First Affiliated Hospital, Sun Yat-Sen University, No. 58, Zhongshan Road II, Guangzhou, Guangdong 510080, China

3 Translational Medicine Research and Development Center, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, No. 1068 Xueyuan Avenue, Shenzhen, Guangdong 518055, China

4 Department of Radiology, the First Affiliated Hospital, Gannan Medical University, No. 23, Qingnian Road, Ganzhou, Jiangxi 341000, China

5 Department of Orthopedics, the First Affiliated Hospital, Gannan Medical University, No. 23, Qingnian Road, Ganzhou, Jiangxi 341000, China

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Diagnostic Pathology 2014, 9:6  doi:10.1186/1746-1596-9-6

Published: 20 January 2014


Myxofibrosarcoma is a myxoid variant of malignant fibrous histiocytoma that most commonly involves the extremities of elderly people. However, a primary myxofibrosarcoma with bone invasion in young adults is extremely rare. Herein, we report the case of a 31-year-old male with a gradually enlarging left thigh mass, who had a history of left femur fracture and received an open reduction and internal fixation with titanium alloy plates and screws 33 months previously. Imaging investigations revealed an irregularly shaped soft tissue mass around the left femur shaft and a partial bone defect in the middle one-third of the left femur. Pathological examination of the resected specimen showed a multi-nodular appearance, abundant myxoid matrix and elongated curvilinear capillaries. Immunohistochemical studies revealed that the tumor cells was positive for VIM and MDM2, and was negative for CK, MSA, SMA, DES, S-100 and CD34. Labeling index of Ki-67 was 25%. Based on the morphological finding and immunostaining, it was diagnosed as a low-grade myxofibrosarcoma. The clinical and imaging examinations did not reveal the evidence of a primary cancer elsewhere, and the patient had no personal or family history of malignancy. To our knowledge, this is the first case of a primary myxofibrosarcoma developed following a fracture and metal implantation in young adults.

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Myxofibrosarcoma; Femur; Fracture; Titanium alloy; Metal implantation