Email updates

Keep up to date with the latest news and content from Diagnostic Pathology and BioMed Central.

Open Access Highly Accessed Open Badges Research

The expression and clinical significance of miR-132 in gastric cancer patients

Xiaowen Liu12, Hongmei Yu12, Hong Cai12 and Yanong Wang12*

Author Affiliations

1 Department of Gastric Cancer and Soft Tissue Sarcoma, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai 200032, People’s Republic of China

2 Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China

For all author emails, please log on.

Diagnostic Pathology 2014, 9:57  doi:10.1186/1746-1596-9-57

Published: 12 March 2014


Background and objective

miR-132 plays a role in regulating neuronal morphology and cellular excitability. Little is known about the effects of miR-132 in cancer. The aim of this study is to evaluate the expression of miR-132 and its clinical significance in gastric cancer.


Cancerous tissues and corresponding normal tissues from 79 patients with gastric cancer were examined for the expression of miR-132 using quantitative PCR and the association between miR-132 expression levels and clinicopathological factors and prognosis was analyzed.


In 79 clinical samples of gastric cancer patients, miR-132 expression levels in cancer tissues were significantly higher than those in the corresponding normal tissues (P = 0.001). Higher expression levels of miR-132 were associated with more frequent lymph node metastasis (P = 0.033), more lymphatic tumor emboli (P = 0.007), and more advanced stage (P = 0.016). Additionally, expression of miR-132 was an independent prognostic factor for overall survival (P = 0.020).


miR-132 could serve as an efficient prognostic factor for gastric cancer patients.

Virtual slides

The virtual slide(s) for this article can be found here: webcite

Gastric cancer; Prognosis; Biological markers