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Meta-analyses between 18 candidate genetic markers and overweight/obesity

Linlin Tang1, Huadan Ye1, Qingxiao Hong1, Fei Chen1, Qinwen Wang13, Leiting Xu13, Shizhong Bu13, Qiong Liu13, Meng Ye2*, Dao Wen Wang4*, Yifeng Mai2* and Shiwei Duan13*

Author Affiliations

1 Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, 315211 Ningbo, Zhejiang, China

2 The Affiliated Hospital, Ningbo University, 315000 Ningbo, Zhejiang, China

3 Diabetes Center, School of Medicine, Ningbo University, Ningbo 315211, Zhejiang, China

4 Institute of Hypertension and Department of Internal Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China

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Diagnostic Pathology 2014, 9:56  doi:10.1186/1746-1596-9-56

Published: 12 March 2014



The goal of our study is to investigate the associations between 18 candidate genetic markers and overweight/obesity.


A total of 72 eligible articles were retrieved from literature databases including PubMed, Embase, SpingerLink, Web of Science, Chinese National Knowledge Infrastructure (CNKI), and Wanfang. Meta-analyses of 18 genetic markers among 56,738 controls and 48,148 overweight/obese persons were done by Review Manager 5.0.


Our results showed that SH2B1 rs7498665 polymorphism was significantly associated with the risk of overweight/obesity (overall odds ratio (OR) = 1.21, 95% confidence interval (CI) = 1.09-1.34, P = 0.0004). Increased risk of overweight/obesity was also observed in FAIM2 rs7138803 polymorphism (overall OR = 1.11, 95% CI = 1.01-1.22, P = 0.04).


Our meta-analyses have shown the important role of 2 polymorphisms (SH2B1 rs7498665 and FAIM2 rs7138803) in the development of overweight/obesity. This study highlighted the importance of above two candidate genes (SH2B1 and FAIM2) in the risk of overweight/obesity.

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SH2B1; FAIM2; Polymorphism; Overweight; Obesity; Meta-analysis