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Duodenal gangliocytic paraganglioma, a rare entity among GEP-NET: a case report with immunohistochemical and molecular study

Fabiana Tatangelo1, Monica Cantile1*, Alessia Pelella1, Nunzia Simona Losito1, Giosuè Scognamiglio1, Franco Bianco2, Andrea Belli2 and Gerardo Botti1

Author Affiliations

1 Pathology Division, Istituto Nazionale Tumori “Fondazione G Pascale”-IRCCS, Naples, Italy

2 Division of Surgical Oncology, Istituto Nazionale Tumori “Fondazione G Pascale”-IRCCS, Naples, Italy

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Diagnostic Pathology 2014, 9:54  doi:10.1186/1746-1596-9-54

Published: 12 March 2014


Gastroenteropancreatic neuroendocrine tumors are the most incident neuroendocrine tumors. In the new WHO classification (2010) the embryological derivation of each neoplastic entity is one of the most important parameters. Gangliocytic Paraganglioma is a tumor originating in the hindgut, a rare neoplasm, generally affecting the second portion of the duodenum, the majority of which are benign.

Cases of gangliocytic paraganglioma with local metastasis or local recurrence have also been reported.

We describe a GP in a 48-year-old caucasian male with an unusual site (4th portion of duodenum) and an interesting immunohistochemical and molecular pattern. In particular, we examined the expression of some neuroendocrine markers and a marker of neuronal differentiation, NeuroD1, whose expression can help to better understand the nature of this neoplasia.

Virtual slides

The virtual slides for this article can be found here: webcite

Gangliocytic paraganglioma; ND markers; Neuro D1