Table 1

Age, gender, clinical signs, inflammatory and morphological changes and colonization status of Helicobacter spirochetes
Dog no. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15
Gendera M F M M M F F M F F F F M M M
Ageb 1 3 1 2 3 1 2 3 3 1 3 1 2 1 3
Clinical signsc MD, W,A H MD, W,A H MD, W,A MD, W,A H H H MD, W,A H H MD, W,A H H
Persistence of Helicobacter spirochetes Mucosal surface + + + + + + + + + + + + + + +
Crypt + + + - - + - - - + - + + - -
Helicobacter spirochete colonization statusd +3 +2 +2 +1 +1 +2 +1 +1 +1 +3 +1 +2 +1 +2 +1
Inflammatory cell Infiltratione LP + + + + + + + + + + + + + + +
N + + + - - + - - - + - + + - -
E + - + - - - - - - + - - - - -
M - + + - - + + - + + - - + + +
Lymphoid folliclesf +2 +2 +2 0 0 +3 +1 0 +1 +3 0 +2 +1 +1 +1
Morphological changes Surface epithelial injury + + + - + + - - + + - + + + -
Crypt hyperplasia - - + - + - + - + + - - - - +
Crypt dilation/distortion + - + - + - + - + + - - - - -
Mucosal fibrosis and atrophy + + + - - + + - - + - + - + -
Severity of inflammatory and morphological changesg Mi Mo Ma No Mi Ma Mi No Mi Ma No Mo Mi Mo Mi

aM = male; F = female.

b1 ≤ one year-old age; one year-old age < 2 ≤ five year-old age.

cA = anorexia; H = healthy; MD = mild diarrhea; W = weight loss.

d0 = [M = 0]; +1 = [M ≤ 10]; +2 = [10 < M ≤ 50]; +3 = [M ≥ 50]; [M = Mean Helicobacter spirochetes number in 10 microscopic field (Giemsa, ×1000)].

eLP = lymphocytes and plasma cells; N = neotrophils; E = eosinophils; Mmacrophage.

f0 = without lymphoid follicle; +1 = presence of one lymphoid follicle; +2 = presence of two lymphoid follicles; +3 = presence of three or more than three lymphoid follicles.

gNo = normal (healthy dog); Mi = mild (Leukocytes appearance ≤ 10, with mild morphologic changes); Mo = moderate (10 < leukocytes ≤ 50, with moderate morphological changes); Ma = marked (leukocytes ≥ 50, with marked morphological changes).

Abdi et al.

Abdi et al. Diagnostic Pathology 2014 9:50   doi:10.1186/1746-1596-9-50

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