Table 4

Diagnostic values of combined detection of BRAF mutation and various DNA methylation markers on FNAB specimens for PTC detection [percent (PTCs with BRAF mutation or methylation-positive/total PTCs, sensitivity; benign nodules with BRAF mutation or methylation-negative/total benign nodules, specificity; PTCs with BRAF mutation or methylation-positive/total positive cases, PPV; benign nodules with BRAF mutation or methylation-negative/total negative nodules, NPV)]
Cut-off values Training group (n =79)
Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
BRAFV600E N/A 71.43 (30/42) 100 (37/37) 100 (30/30) 75.51 (37/49) 71.43
CALCA + BRAFV600E 8.022 71.43 (30/42) 100 (37/37) 100 (30/30) 75.51 (37/49) 71.43
DAPK1 + BRAFV600E 0.64 78.57 (33/42) 100 (37/37) 100 (33/33) 80.43 (37/46) 78.57
TIMP3 + BRAFV600E 6.46 73.81 (31/42) 100 (37/37) 100 (31/31) 77.08 (37/48) 73.81
RAR-beta + BRAFV600E 11.21 73.81 (31/42) 100 (37/37) 100 (31/31) 77.08 (37/48) 73.81
RASSF1A + BRAFV600E 0.003 76.19 (32/42) 100 (37/37) 100 (32/32) 78.72 (37/47) 76.19
All five genes + BRAFV600E N/A 85.71 (36/42) 100 (37/37) 100 (36/36) 86.05 (37/43) 85.71
Cut-off values Test group (n =38)
Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
BRAFV600E N/A 70.00 (14/20) 100 (18/18) 100 (14/14) 75.00 (18/24) 70.00
CALCA + BRAFV600E 8.022 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
DAPK1 + BRAFV600E 0.64 80.00 (16/20) 94.44 (17/18) 94.12 (16/17) 80.95 (17/21) 74.44
TIMP3 + BRAFV600E 6.46 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
RAR-beta + BRAFV600E 11.21 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
RASSF1A + BRAFV600E 0.003 75.00 (15/20) 100 (18/18) 100 (15/15) 78.26 (18/23) 75.00
All five genes + BRAFV600E N/A 85.00 (17/20) 94.44 (17/18) 94.44 (17/18) 85.00 (17/20) 79.44

Zhang et al.

Zhang et al. Diagnostic Pathology 2014 9:45   doi:10.1186/1746-1596-9-45

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