Table 3

Diagnostic values of BRAF mutation and various DNA methylation markers testing on FNAB specimens for PTC detection [percent (PTCs with BRAF mutation or methylation-positive/total PTCs, sensitivity; benign nodules with BRAF mutation or methylation-negative/total benign nodules, specificity; PTCs with BRAF mutation or methylation-positive/total positive cases, PPV; benign nodules with BRAF mutation or methylation-negative/total negative nodules, NPV)]
Genes Cut-off values Sensitivity (%) Specificity (%) PPV (%) NPV (%) Accuracy (%)
BRAFV600E N/A 71.43 (30/42) 100 (37/37) 100 (30/30) 75.51 (37/49) 71.43
CALCA 2.405 33.33 (14/42) 81.08 (30/37) 66.67 (14/21) 51.72 (30/58) 14.41
DAPK1 0.003 66.67 (28/42) 83.78 (31/37) 82.35 (28/34) 68.89 (31/45) 50.45
TIMP3 1.038 30.95 (13/42) 75.68 (28/37) 59.09 (13/22) 49.12 (28/ 57) 6.63
RAR-beta 1.606 30.95 (13/42) 75.68 (28/37) 59.09 (13/22) 49.12 (28/57) 6.63
RASSF1A 5.311 61.90 (26/42) 78.38 (29/37) 76.47 (26/34) 62.22 (28/45) 40.28
All five genes N/A 88.10 (37/42) 75.68 (28/37) 80.43 (37/46) 84.85 (28/33) 63.69

PPV, Positive predictive value; NPV, Negative predictive value.

Zhang et al.

Zhang et al. Diagnostic Pathology 2014 9:45   doi:10.1186/1746-1596-9-45

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