Table 5

Comparison of podocin immunostain with other studies
Authors No. of cases MCD FSGS IgAN MGN Henoch Schoenlein purpura nephritis
Horinouchi et al (2003) [10]Pediatric and adult Total 6 19 6 5 6
Absent staining 0 7(36.84%) 0 0 0
1+ 0 7(36.84%) 0 1(15%) 0
2+ 0 4(21.05%) 0 19(15%) 0
3+ 6(100%) 1(5.2%) 6(100%) 3(60%) 6(100%)
Mao J et al (2006) [11]Pediatric Total 9 - 6 - -
Podocin fluorescence intensity Not reduced Not reduced
Koop et al (2003) [6]Adult Total 10 5 10 1
Podocin IHC intensity quantification by image analysis Reduced Reduced Not altered Reduced -
Podocin mRNA levels Increased Increased Decreased Increased -
Guan N et al (2002) [12]Pediatric Total 9 - 4 - -
Podocin staining intensity Decreased Not decreased Not decreased - -
Present study Total 22 21 20 25 -
Absent staining 0 0 0 0 -
1+ 0 0 0 0 -
2+ 6(27.27%) 7(33.33%) 3(15%) 8(32%) -
3+ 16(72.72%) 14(66.66%) 17(85%) 17(68%) -

Note; MCD-Minimal change disease, FSGS-focal segmental glomerulosclerosis, IgA N-IgA nephropathy, MGN-Membranous glomerulonephritis.

Shankar et al.

Shankar et al. Diagnostic Pathology 2014 9:40   doi:10.1186/1746-1596-9-40

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