Table 3

Staining pattern of glomeruli and tubules with beta dystroglycan in MCD, FSGS, IGAN and MGN
Histological parameters Degree Groups P value
MCD FSGS IgAN MGN
Glomerular staining of Absent n(%) 4(18.1%) 4(19.0%) 4(20.0%) 1(4.0%) 0.975 NS
beta-dystroglycan Mild n(%) 4(18.1%) 3(14.2%) 6(30.0%) 4(16.0%)
Moderate n(%) 10(45.4%) 10(47.6%) 7(35.0%) 7(28.0%)
Intense n(%) 4(18.1%) 4(19.0%) 3(15.0%) 13(52.0%)
Tubules (PCT) staining pattern of Absent n(%) 8(36.3%) 5(23.8%) 15(75.00% 11(44.0%) 0.009 *
beta dystroglycan Mild n(%) 0 2(9.5%) 0 3(12.0%)
Moderate n(%) 4(18.1%) 9(42.8%) 5(25.00%) 8(32.0%)
Intense n(%) 10(45.4%) 5(23.8%) 0 3(12.0%)
Tubules (DCT) staining pattern of Absent n(%) 2(9.0%) 2(9.5) 7(35.0%) 3(12.0%) 0.92 NS
beta dystroglycan Mild n(%) 0 0 0 2(8.0%)
Moderate n(%) 6(27.2%) 5(23.8%) 7(35.0%) 7(28.0%)
Intense n(%) 14(63.6%) 14(66.6%) 6(30.0%) 13(52.0%)
% Tubular staining <30% n(%) 6(27.27%) 5(23.8%) 10(50.0%) 6(24.0%) <0.001*
30-60% n(%) 10(45.4%) 6(28.5%) 0 3(12.0%)
>60% n(%) 6(27.2%) 10(47.6%) 10(50.0%) 16(64.0%)

Note; MCD-Minimal change disease, FSGS-focal segmental glomerulosclerosis, IgA N-IgA nephropathy, MGN-Membranous glomerulonephritis, NS-not significant, PCT-proximal convoluted tubules, DCT-distal convoluted tubules, *- statistically significant.

Shankar et al.

Shankar et al. Diagnostic Pathology 2014 9:40   doi:10.1186/1746-1596-9-40

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