Table 3

“Submucosa invasion-associated” pathologic factors in 616 validation cohorts
Variables Depth of invasion P value
Submucosa (%) Mucosa (%)
WHO histologic grade <0.0001
  Well 114 (59.1) 322 (76.1)
  Moderate 34 (17.6) 47 (11.1)
  Poor 45 (23.3) 54 (12.8)
Poorly differentiated tumor <0.0001
  Absent 99 (51.3) 301 (71.2)
  Present 94 (48.7) 122 (28.8)
Islands of muscularis mucosa 0.0008
  Absent 160 (82.9) 389 (92.0)
  Present 33 (17.1) 34 (8.0)
Cribriform pattern 0.9943
  Absent 188 (97.4) 412 (97.4)
  Present 5 (2.6) 11 (2.6)
Papillary architecture 0.1327
  Absent 132 (68.4) 314 (74.2)
  Present 61 (31.6) 109 (25.8)
Intraglandular eosinophilic necrotic debris 0.5814
  Absent 128 (66.3) 290 (68.6)
  Present 65 (33.7) 133 (31.4)
Desmoplastic reaction 0.0934
  Absent 190 (98.4) 422 (99.8)
  Present 3 (1.6) 1 (0.2)
Total numbers 193 423

Lee et al.

Lee et al. Diagnostic Pathology 2014 9:34   doi:10.1186/1746-1596-9-34

Open Data