Significance of ERβ expression in different molecular subtypes of breast cancer
1 Department of Breast, Digestive & Vascular Center, First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinjiang 830054, P. R. China
2 Department of Pathology, First Affiliated Hospital of Xinjiang Medical University, No. 137, South Liyushan Road, Xinjiang 830054, P. R. China
Diagnostic Pathology 2014, 9:20 doi:10.1186/1746-1596-9-20Published: 23 January 2014
This study is to investigate the estrogen receptor β (ERβ) expression in molecular subtypes of breast cancer and clinic significance of ERβ expression.
The ERβ expression was detected in 730 cases of breast cancer tissue specimens by immunohistochemistry. Twenty-one patients were censored during 2–10 years follow-up. The difference in ERβ expression was analyzed by Pearson Chi-square Test. Its correlation with estrogen receptor α (ERα), progesterone receptor (PR) and human epidermal growth factor receptor 2 (Her-2) was analyzed by Spearman rank correlation. The accumulative tumor-free survival rate was calculated by Kaplan-Meier method and difference in survival rate was analyzed by Log-rank test. Cox regression was used for multi-factor analysis.
The ERβ expression was significantly different among the molecular subtypes of breast cancer (P < 0.05). The ERβ expression in breast cancer was positively correlated with Her-2 (P < 0.05) while it had no correlation with ERα and Her-2. The expression of ERα was negatively correlated with Her-2 (P < 0.01) whereas positively correlated with PR (P < 0.01). The expression of PR was negatively correlated with Her-2 (P < 0.05). The tumor-free survival rate in patients with positive ERβ expression was significantly lower than that in patients with negative ERβ expression.
Positive ERβ expression is a poor prognostic factor of breast cancer.
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