Table 3

Total and stratified analysis of the RAD51 135G/C polymorphism on risk of the four cancers
Variables No.a Case/Control GG vs. CC GC vs. CC GG+GC vs. CC GG vs. GC+CC
OR(95% CI) Pb P OR(95% CI) Pb P OR(95% CI) Pb P OR(95% CI) Pb P
Total cancer types 22 6836/8507 0.83(0.43–1.59) 0.00c 0.57 0.90(0.39–2.08) 0.00c 0.81 0.82(0.39–1.73) 0.00c 0.60 0.84(0.69–1.02) 0.00c 0.08
SCCHN 4 1237/1340 2.46(1.08–5.61) 0.50 0.03 2.20(0.30–16.22) 0.02 0.44 2.50(0.76–8.28) 0.25 0.13 0.84(0.40–1.75) 0.00c 0.64
CC 4 753/720 0.92(0.08–10.55) 0.00c 0.95 0.65(0.05–8.08) 0.00c 0.74 0.79(0.06–10.16) 0.00c 0.85 1.12(0.53–2.35) 0.00c 0.77
OC 5 2001/2420 0.42(0.10–1.78) 0.0007 0.24 0.41(0.06–2.67) 0.00c 0.35 0.40(0.07–2.18) 0.00c 0.29 0.80(0.62–1.03) 0.07 0.09
AL 9 2845/4027 0.82(0.49–1.39) 0.26 0.47 1.00(0.59–2.08) 0.29 0.99 0.85(0.50–1.44) 0.25 0.60 0.82(0.63–1.07) 0.002 0.14
Source of controls
HCC 13 3409/4126 0.77(0.30–1.98) 0.00c 0.58 0.79(0.24–2.60) 0.00c 0.70 0.74(0.26–2.13) 0.00c 0.58 0.82(0.60–1.12) 0.00c 0.20
PCC 9 3427/4381 0.93(0.53–1.62) 0.87 0.79 1.14(0.64–2.02) 0.87 0.66 0.95(0.54–1.67) 0.88 0.87 0.88(0.71–1.09) 0.01 0.25
Ethnicity
Asian 3 1170/1866 0.92(0.27–3.19) 0.01 0.90 0.98(0.28–3.40) 0.01 0.97 0.94(0.27–3.26) 0.009 0.92 0.94(0.77–1.14) 0.64 0.52
Caucasian 18 5616/6611 0.80(0.36–1.79) 0.00c 0.59 0.86(0.31–2.38) 0.00c 0.77 0.79(0.32–1.95) 0.00c 0.61 0.83(0.65–1.05) 0.00c 0.13
African 1 50/30 0.75(0.06–8.70) 0.82 1.50(0.10–23.07) 0.77 0.83(0.07–9.54) 0.88 0.55(0.16–1.90) 0.34

aNumber of studies.

bP value of Q-test for heterogeneity test.

cFixed-effects model was used when P value for heterogeneity test <0.10, otherwise, random-effects model was used.

SCCHN: squamous cell carcinoma of the head and neck; CC: colorectal cancer; OC: ovarian cancer; AL: acute leukaemia.

Cheng et al.

Cheng et al. Diagnostic Pathology 2014 9:18   doi:10.1186/1746-1596-9-18

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