Table 2

Review from the literature of 61 reported patients with oligodendroglioma with metastases outside the CNS
Patient no. Gender Subjects WHO grade Age at diagnosis (y) Location of metastasis OS (months) Time between presentation of primary tumor and metastasis (months) Molecular biomarkers tested Reference
1 F British ODG, low grade early, later *AO 25 Cervical lymph nodes, scalp, lung, bone 84 * * James et al. 1951 [26]
2 F American ODG, *grade 7 Scalp, bone, soft tissue, liver 36 * * Spataro et al. 1968 [27]
3 F Austrian ODG, *grade 58 Bone 30 * * Jellinger et al. 1969 [28], (also reported as Schuster et al. 1976 [29])
4 M American *ODG, *grade 45 Bone marrow 17 * * Smith et al. 1969 [2]
5 * * ODG, initially low grade 3.5 Lymph nodes, lungs, adrenal 21 * * Kernohan 1971 [30]
6 F Scottish Malignant glioma, some ODG features 21 Bone 9 * * Eade et al. 1971 [31]
7 M Scottish Small cell GBM with regions of ODG 23 Bone 12 * *
8 M French *ODG, *grade 57 Lymph nodes, bone 20 * * Cappellaere et al. 1972 [32]
9 M French *ODG, *grade 22 Lymph nodes, bone, parotid gland 25 * *
10 F British Malignant glioma, some ODG features 30 Pleura 156 * * Brander et al. 1975 [33]
11 M German *ODG, *grade 40 Bone, lymph nodes, lungs 86 * * Kummer et al. 1977 [34]
12 * Canadian *ODG, *grade * Scalp * * * Chin et al. 1980 [35]
13 F American ODG, grade II 33 Bone, lymph nodes, scalp, soft tissue 50 * * Ordonez et al. 1981 [36]
14 M Japanese Grade III 32 Bone 76 14 * Nakamura et al. 1985 [37]
15 M * ODG, malignant 41 Bone marrow 48 * * Newman et al. 1985 [38]
16 * Canadian ODG, *grade, some astro 12 Bone, lymph nodes, scalp 104 * * Macdonald et al. 1989 [39]
17 * Canadian ODG, *grade 44 Cervical lymph nodes, bone, 48 * *
18 F Canadian ODG, grade III 36 Bone, lymph nodes 60 * *
19 * Canadian ODG, *grade, some astro 32 Bone, lymph nodes, scalp 38 * *
20 * Canadian ODG, *grade 34 Bone 76+ * *
21 M Canadian ODG, grade III 27 Bone 37 * *
22 * Canadian ODG, *grade, some astro 47 Bone 26+ * *
23 * Polish Grade III * * * * * Rolski et al. 1993 [40]
24 * German * * Cervical lymph nodes * * * Steininger et al. 1993 [41]
25 M British ODG, grade III 54 Bone marrow 12 * * Gerrard et al. 1995 [42]
26 * German Grade III * Cervical lymph nodes * 48 * Schroder et al. 1995 [43]
27 M Italian ODG, grade II 58 Chest wall, bone marrow, possibly liver 48 * * Monzani et al. 1996 [44]
28 M British ODG, grade III 43 Bone marrow, liver 3 * * Dawson 1997 [45]
29 M Austrian ODG-astrocytoma grade III 62 Thoracic wall, pleura, bone marrow 288 6 * Finsterer et al. 1998 [46]
30 M Indian Grade III 50 Bone and bone marrow 7+ * * Anand et al. 2001 [47]
31 * Italian ODG, grade II 25 Bone 84+ * * Giordana et al. 2002 [48]
32 M Indian Grade III 50 Bone marrow 17 * * Sharma et al. 2003 [49]
33 M American Grade III 33 Bone marrow 38+ * * Choon et al. 2004 [50]
34 M Canadian Grade III 35 Bone 84 23 Allelic LOH of chromosome 1p (1p-), a rise in serum alkaline phosphatase Morrison et al. 2004 [51]
35 F American ODG, grade II early, later AO, grade III 41 Parotid gland 79+ 68 Codeletion of 1p/19q Wang et al. 2004 [52]
36 M American ODG, low grade early, later AO, grade III 28 Bone marrow 120 5 Positive for S-100 marker with immunohistochemical stain Al-Ali et al. 2005 [23]
37 M American Atypical meningioma, early, later AO, grade III 32 Bone, bone marrow, cervical and thoracic lesions 168 27 Elevated serum lactate dehydrogenase and alkaline phosphatase, positive for S-100, and GFAP with immunohistochemical stain Merrell et al. 2006 [53]
38 F American AO, grade III 71 Bone, bone marrow, 17 13 Codeletion of 1p/19q, positive for S-100, and GFAP with immunohistochemical stain, elevated serum hemoglobin level
39 F Chinese ODG, *grade 64 Pleura, bone * 84 Positive for S-100, Olig2 and GFAP with immunohistochemical stain Lee et al. 2006 [54]
40 M American ODG, grade II early, later AO, grade III 15 Pleura, bone, lungs, adrenal gland, chest, liver, abdomen 62 31 Codeletion of 1p/19q Bruggers et al. 2007 [55]
41 F Japanese AO, grade III 17 Spleen, liver, pancreas, bone, spinal dura mater, dorsal root ganglia, lungs, lymph nodes, iliopsoas muscle 144 3 Markedly positive for Ki-67, and positive for Olig2 with immunohistochemical stain, Uzuka et al. 2007 [56]
42 F Korean AO, grade III 48 Liver, lungs 28 27 Not presented Han et al. 2008 [4]
43 M Italian AO, grade III 40 Bone, bone marrow, liver 10 5 Not presented Zustovich et al. 2008 [57]
44 F Slovenian AO, grade III 54 Cervical and neck lymph nodes 48 12 Positive for S-100, and GFAP with immunohistochemical stain Volavsek et al. 2009 [58]
45 F Slovenian AOA, grade III 30 Bone 58+ 17 Positive for GFAP with immunohistochemical stain
46 M Japanese AO, grade III 53 Lymph nodes, bone, spinal dura mater, thymus gland, chest wall 30 24 Codeletion of 1p/19q Noshita N, et al. 2010 [59]
47 F Japanese AO, grade III 73 Cervical lesion 18+ 18 * Oshiro S, et al. 2010 [60]
48 M Dutch AO, grade III 59 Bone marrow 33 31 Codeletion of 1p/19q, positive for S-100, and p53 with immunohistochemical stain Krijnen JL, et al. 2010 [61]
49 M Dutch *ODG, *grade 24 Bone marrow * 84 Not presented
50 M Dutch AO, grade III 34 Cervical lymph nodes, iliopsoas muscle * not presented Not presented
51 M Dutch AO, grade III 64 Axillary lymph nodes * 34 Not presented
52 M Dutch AO, grade III 72 Bone marrow * 6 Not presented
53 F Dutch *ODG, *grade 67 Bone marrow * 29 Not presented
54 M Dutch AO, grade III 62 Retroperitoneal lymph nodes * 21 Not presented
55 M Turkish AO, grade III 55 Bone marrow 23+ 11 Positive for GFAP with immunohistochemical stain Kural C, et al. 2011 [62]
56 M Chinese AO, grade III 37 Bone 58+ 37 Positive for S-100, and GFAP with immunohistochemical stain Wu Y, et al. 2011 [63]
57 M Italian AO, grade III 40 Bone marrow 61 57 Positive for enolase, and GFAP with immunohistochemical stain Cordiano V, et al. 2012 [64]
58 F Turkish ODG, *grade * Cervical lymphatic chain * 60 Codeletion of 1p/19q Can B, et al. 2012 [65]
59 M Turkish AO, grade III 58 Breast * * * Alacacioglu A, et al. 2012 [66]
60 M Irish AO, grade III 58 Bone 120+ 108 Codeletion of 1p/19q, positive for GFAP with immunohistochemical stain Greene J, et al. 2013 [67]
61 M Chinese AO, grade III 45 Bone, bone marrow, lymph nodes 16 13 No deletion of 1p/ 19q, PTEN mutation in exon 2, MGMT promoter methylated, positive for IDH1, Ki-67, Olig2, and GFAP, negative for MGMT, EMA and Vim with immunohistochemical stain Present case

F: female, M: male, OS: overall survival, WHO: World Health Organization, LOH: loss of heterozygosity, ODG: oligodendroglioma, AO: anaplastic oligodendroglioma, AOA: anaplastic oligoastrocytoma, GBM: glioblastoma multiforme.

*Not provided in the corresponding literature.

+ alive at publication.

Li et al.

Li et al. Diagnostic Pathology 2014 9:17   doi:10.1186/1746-1596-9-17

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