Table 1

Characteristics of included studies
Author Year Country Ethnicity Source Genotyping method Cancer type Total number Cases Controls HWE of controls
Cases Controls Lys/Lys Lys/Gln Gln/Gln Lys/Lys Lys/Gln Gln/Gln
Sturgis [26] 2000 America Caucasian HB PCR-RFLP SCCHN 189 496 75 83 31 218 221 57 0.9304
Gajecka [21] 2005 Poland Caucasian HB PCR-RFLP LC 293 320 110 135 48 87 175 58 0.0659
Huang [23] 2005 America Caucasian Mix* TaqMan-PCR HNC 425 683 176 188 61 296 292 95 0.0951
Rydzanicz [24] 2005 Poland Caucasian HB PCR-RFLP HNC 172 143 69 73 30 54 64 25 0.4265
Kietthubthew [32] 2006 Thailand Asian PB PCR-RFLP SCCOC 105 164 83 21 1 126 36 2 0.7489
Matullo [25] 2006 Europe Caucasian nest TaqMan-PCR UADC 82 1094 34 39 9 397 504 193 0.1330
Ramachandran [37] 2006 India Asian HB PCR-RFLP OC 110 110 49 46 15 71 31 8 0.0908
An [22] 2007 America Caucasian HB PCR-RFLP SCCHN 829 854 330 394 105 358 386 110 0.7091
Bau [27] 2007 Taiwan Asian HB PCR-RFLP OC 154 105 134 18 2 89 15 1 0.6824
Yang [29] 2007 China Asian PB PCR-RFLP NPC 153 168 128 24 1 124 43 1 0.1805
Majumder [31] 2007 India Asian HB PCR-RFLP OC 309 388 158 125 26 190 158 40 0.4030
Harth [35] 2008 Germany Caucasian HB PCR-RFLP SCCHN 312 300 111 154 47 108 149 43 0.4642
Mitra [34] 2009 North India Caucasian HB PCR-RFLP SCCHN 275 385 88 148 39 163 179 43 0.5571
Jelonek [33] 2010 Poland Caucasian HB PCR-RFLP HNC 103 110 29 52 22 38 60 12 0.1030
Ji [28] 2010 Korea Asian HB PCR-SBE SCCHN 267 348 232 32 3 298 48 2 0.9645
Stembalska [38] 2011 Poland Caucasian HB PCR-RFLP LSCC 60 100 20 26 14 32 46 22 0.4795
Kumar [36] 2012 North India Caucasian HB PCR-RFLP SCCHN 278 278 92 125 61 129 110 39 0.0531
Yuan [30] 2012 China Asian PB TaqMan-PCR HNC 394 887 333 57 4 752 129 6 0.8556

HB hospital-based study, PB population-based study, *two population-based studies and one hospital-based study, nest nested case–control study, PCR-RFLP polymerase chain reaction-restriction fragment length polymorphism, PCR-SBE polymerase chain reaction-single base extension, HNC head and neck cancer, SCCHN squamous cell cancer of the head and neck, NPC nasopharyngeal cancer, LC laryngeal cancer, LSCC laryngeal squamous cell cancer, UADC upper aerodigestive tract cancer, OC oral cance, HWE Hardy–Weinberg equilibrium.

Lin et al.

Lin et al. Diagnostic Pathology 2014 9:15   doi:10.1186/1746-1596-9-15

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