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Open Access Highly Accessed Research

Lack of association between a functional polymorphism (rs1800796) in the interleukin-6 gene promoter and lung cancer

Weihua Wang*, Jie Chen, Feng Zhao, Burong Zhang and Hongsheng Yu

Author Affiliations

The Affiliated Hospital of Medical College of Ningbo University, Ningbo 315020 Zhejiang, China

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Diagnostic Pathology 2014, 9:134  doi:10.1186/1746-1596-9-134

Published: 1 July 2014

Abstract

Background

A number of studies have examined the association between interleukin-6 (IL-6) rs1800796 polymorphism and risk of lung cancer but revealed inconsistent results. The aim of this study was to clarify the association between IL-6 rs1800796 polymorphism and risk of lung cancer.

Methods

Literature databases including PubMed, Embase and CNKI were searched up to January 2014. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) under co-dominant model, dominant model and recessive model were estimated using random-effects model.

Results

A total of seven studies, including 2691 lung cancer cases and 3067 controls, were included in the meta-analysis. The results suggested that IL-6 rs1800796 polymorphism was not associated with risk of lung cancer under homogeneous co-dominant model (OR = 1.06, 95%CI = 0.73-1.54), heterogeneous co-dominant model (OR = 1.24, 95%CI = 0.96-1.60), dominant model (OR = 1.23, 95%CI = 0.95-1.58) and recessive model (OR = 0.96, 95%CI = 0.70-1.32). The association was still not significant in either never-smokers (OR = 1.19, 95%CI = 0.95-1.48) or ever-smokers (OR = 1.73, 95%CI = 0.89-3.36).

Conclusion

The present meta-analysis suggested that there was no association between IL-6 rs1800796 polymorphism and lung cancer, which was independent of smoking status.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/1060061508127855 webcite

Keywords:
Interleukin-6; Lung cancer; Polymorphism; Meta-analysis