A huge malignant solitary fibrous tumor of kidney: case report and review of the literature
1 Department of Medical Oncology, Affiliated Cancer Hospital of Guangzhou Medical University, Guangzhou, China
2 Department of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China
3 Department of Radiology, Nanfang Hospital, Southern Medical University, Guangzhou, China
4 Department of Imaging Center, Nanfang Hospital, Southern Medical University, Guangzhou, China
5 Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China
Diagnostic Pathology 2014, 9:13 doi:10.1186/1746-1596-9-13Published: 20 January 2014
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Solitary fibrous tumor (SFT) is a spindle cell neoplasm that rarely occurs in the kidney. Malignant SFT of the kidney is particularly rare. Here, we report a 66-year old woman with a right flank mass that has been proved clinically and radiographically. Grossly, the largest diameter of the mass were measured up to 23 cm, was poorly circumscribed. Approximately 80% of the neoplasm consisted of hyperchromatic and pleomorphic spindled cells surrounding staghornlike blood vessels. Tumor cells frequently had mitoses and necrosis. However, the remainder of the mass was composed of haphazard, storiform or short fascicular arrangements of spindle cells in a loose myxoid to fibrous stroma. Immunohistochemically, we observed diffusely strong CD34 staining and an 85% Ki-67 proliferative index. The tumor partly showed negative CD34 and a 20% proliferative index. To our knowledge, this is the largest malignant renal SFT in the reported literatures and shows an obviously high proliferative index.