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Open Access Research

Significant association between TAP2 polymorphisms and rheumatoid arthritis: a meta-analysis

Dongjun Dai1, Yong Chen2, Ping Ru1, Xingyu Zhou1, Jianmin Tao1, Huadan Ye1, Qingxiao Hong1, Linlin Tang1, Guanghui Pan1, Danfeng Lin1, Qiongyao Gong2, Yuelong Lv1, Leiting Xu1 and Shiwei Duan1*

Author Affiliations

1 Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, China

2 Department of Rheumatology, Ningbo No.2 Hospital, Ningbo, Zhejiang 315010, China

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Diagnostic Pathology 2014, 9:129  doi:10.1186/1746-1596-9-129

Published: 27 June 2014

Abstract

Background

Rheumatoid arthritis (RA) is a severe chronic immune mediated inflammatory disease that has been shown to be associated with human leukocyte antigen (HLA) loci. The transporter associated with antigen processing 2 (TAP2) has been identified to play an important role in the HLA-associated diseases and immune response. The goal of our meta-analysis was to summarize the contribution of TAP2 polymorphisms to the risk of RA.

Methods

Meta-analyses were performed between RA and 3 TAP2 coding polymorphisms that comprised TAP2-379Ile > Val (rs1800454), TAP2-565Ala > Thr (rs2228396) and TAP2-665Thr > Ala (rs241447). The meta-analyses were involved with 9 studies (24 individual studies) among 973 cases and 965 controls.

Results

Meta-analyses showed that TAP2-379Ile allele was significantly associated with an increased risk of RA (p = 0.0002, odds ratio (OR) = 1.44, 95% confidence interval (CI) = 1.18-1.74). This association was further shown only in the dominant model (p = 0.006, OR = 1.59, 95% CI = 1.14-2.22). Subgroup analyses by ethnicity revealed that the association of TAP2-379Ile was significant in Asians (p = 0.03, OR = 1.38, 95% CI = 1.04-1.83). In addition, another significant association of TAP2-565Thr allele with RA was observed in Europeans (p = 0.002, OR = 1.62, 95% CI = 1.20-2.20).

Conclusions

Our meta-analyses suggested that TAP2-379Ile allele was significantly associated with a 59% increased risk in the dominant effect model. Subgroup analyses by ethnicity showed that TAP2-379-Ile increased the risk of RA by 38% in Asians and TAP2-565Thr increased the risk of RA by 38% in Europeans.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/2097080313124700 webcite

Keywords:
Rheumatoid arthritis; Polymorphism; Meta-analysis; TAP2; Ethnicity