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Unusual presentation of primary T-cell lymphoblastic lymphoma: description of two cases

Maria R Ambrosio1*, Monica Onorati12, Bruno J Rocca13, Alessandro Ginori1, Giuseppe Lobello1, Guido Petracco2, Alessandro Davide Videtta1, Franca Di Nuovo2, Rosa Santopietro4 and Stefano Lazzi4

Author Affiliations

1 Department of Medical Biotechnologies, Section of Pathology, University of Siena, Siena, Italy

2 Section of Pathology, G. Salvini Hospital, Garbagnate Milanese, Italy

3 Section of Pathology, Ospedale di Circolo di Busto Arsizio, Presidio Ospedaliero di Saronno, Saronno, Italy

4 Section of Pathology, Azienda Ospedaliera Universitaria Senese, Siena, Italy

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Diagnostic Pathology 2014, 9:124  doi:10.1186/1746-1596-9-124

Published: 20 June 2014



T-cell lymphoblastic lymphoma comprises approximately 85-90% of all lymphoblastic lymphomas. It often arises as a mediastinal mass, and with bone marrow involvement. Presentation at other sites without nodal or mediastinal localization is uncommon.

Case report

We describe clinical, histologic, immunohistochemical, and molecular features of two cases of primary T-cell lymphoblastic lymphoma arising respectively in uterine corpus and testis. The tumors were composed by medium to large cells, exhibiting a diffuse pattern of growth but sometimes forming indian files or pseudo-rosettes. The neoplastic cells strongly expressed TdT and T-cell markers in both uterine corpus and testis. However, the testis case also showed aberrant expression of B-cell markers, thus molecular biology was necessary to achieve a final diagnosis. T-cell receptor gene rearrangement analysis identified a T-cell origin.


To the best of our knowledge, only one doubtful previous case of primary uterine T-cell lymphoblastic lymphoma and no previous cases of primary testicular T-cell lymphoblastic lymphoma have been reported. Due to the morphology of neoplastic cells, a challenging differential diagnosis with all the tumors belonging to the so-called small round blue cell tumor category is mandatory. In ambiguous lineage cases, molecular biology may represent an adequate tool to confirm diagnosis.

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Lymphoblastic lymphoma; TdT; molecular biology