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Open Access Research

Association of TRPS1 gene with different EMT markers in ERα-positive and ERα-negative breast cancer

Peng Su1, Jing Hu1, Hui Zhang2, Ming Jia1, Weiwei Li1, Xuanxuan Jing1 and Gengyin Zhou1*

Author Affiliations

1 Department of Pathology, Shandong University School of Medicine, 44#, Wenhua Xi Road, 250012 Jinan, Shandong, P.R. China

2 Department of Pathology, Qilu Hospital of Shandong University, Jinan, PR China

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Diagnostic Pathology 2014, 9:119  doi:10.1186/1746-1596-9-119

Published: 16 June 2014

Abstract

Background

Breast cancer is a heterogeneous disease consisting of different subtypes. Trichorhinophalangeal syndrome type 1 (TRPS1) gene, a GATA-type transcription factor, has been found to be highly expressed in breast cancer. Epithelial-to-mesenchymal transition (EMT) is known to play an important role in tumour invasion and metastasis. Our objective was to elucidate the different roles and clinical relevance of TRPS1 in different estrogen receptor (ER) expression subtypes of breast cancer.

Methods

An immunohistochemical study was performed. The correlation between clinicopathological features and other biomarker profiles were analysed statistically.

Result

TRPS1 expression was correlated with the patients’ age (P = 0.017). It was positively related with ERα (P < 0.001), progesterone receptor (PR) (P < 0.001) and ERβ (P = 0.001) status, but negatively associated with Ki67 (P = 0.002) and HER2 (P = 0.025) status. In ERα-positive breast cancer, TRPS1 expression was positively associated with the expression of E-cadherin (P < 0.001), β-catenin(P = 0.001), ERβ (P = 0.03), and p53 (P = 0.002) status, while in ERα-negative breast cancer, TRPS1 expression was correlated with slug (P = 0.004), vimentin (P = 0.003), smooth muscle actin (SMA) (P = 0.031), and IMP3 (P = 0.005) expression.

Conclusions

Based on our findings, we conclude that TRPS1 is positively associated with E-cadherin and β-catenin status in ERα-positive breast cancer cells, while it is also significantly associated with mesenchymal markers of EMT in ERα-negative breast cancer cells. TRPS1 can be a prognostic marker depending on the type of breast cancer.

Virtual Slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/8686515681264281 webcite

Keywords:
TRPS1; Epithelial to mesenchymal transition; Estrogen receptor; Breast cancer