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Significance of 18 F-FDG PET and immunohistochemical GLUT-1 expression for cardiac myxoma

Yukio Okazaki1, Sohsuke Yamada23*, Shohei Kitada2, Iwao Matsunaga1, Eijirou Nogami1, Teruo Watanabe3, Yasuyuki Sasaguri23, Yutaka Honma4 and Tsuyoshi Itou1

Author Affiliations

1 Department of Cardiovascular Surgery, Fukuoka Wajiro Hospital, Fukuoka, Japan

2 Department of Pathology and Cell Biology, School of Medicine, University of Occupational and Environmental Health, 1-1 Iseigaoka, Yahatanishi-ku, Kitakyushu 807-8555, Japan

3 Department of Laboratory of Pathology, Fukuoka Wajiro Hospital, Fukuoka, Japan

4 Department of Nuclear Medicine, Fukuoka Wajiro Hospital, Fukuoka, Japan

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Diagnostic Pathology 2014, 9:117  doi:10.1186/1746-1596-9-117

Published: 16 June 2014


Cardiac tumours are relatively rare and are difficult to diagnose merely with imaging techniques. We demonstrated an unusual case of left atrial myxoma, displaying the successful detection by positron emission tomography using 2-deoxy-2-[18 F] fluoro-D-glucose (18 F-FDG PET), correlated closely to more intense and enhanced immunoreactivity with glucose transporter-1 (GLUT-1) in a substantial number of cardiac myxoma cells. Further prospective studies are needed to validate the significance of 18 F-FDG PET findings for cardiac myxoma and the association with immunohistochemical GLUT-1 expression in its tumour cells, after collecting and investigating a larger number of surgical cases examined with both of them.

Virtual slides

The virtual slide(s) for this article can be found here: webcite

Cardiac myxoma; 18 F-FDG PET; Immunohistochemistry; GLUT-1