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Open Access Research

Association of CYP1B1 L432V polymorphism with urinary cancer susceptibility: a meta-analysis

Weifan Jiang1*, Guang Sun2, Jianhua Xiong1, Xiaoqing Xi1 and Zimin Shi1

Author Affiliations

1 Department of Urology, the Second Affiliated Hospital, Nanchang University, Nanchang, China

2 Department of Urology, The Second Hospital of Tianjin Medical University, Tianjin Institute of Urology, Tianjin, China

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Diagnostic Pathology 2014, 9:113  doi:10.1186/1746-1596-9-113

Published: 9 June 2014

Abstract

Background

The Cytochrome P450 1B1 (CYP1B1) is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates. Previous studies have reported the existence of CYP1B1 L432V missense polymorphism in prostate, bladder and renal cancers. However, the effects of this polymorphism on the risk of these cancers remain conflicting. Therefore, we performed a meta-analysis to assess the association between L432V polymorphism and the susceptibility of urinary cancers.

Methods

We searched the PubMed database without limits on language for studies exploring the relationship of CYP1B1 L432V polymorphism and urinary cancers. Article search was supplemented by screening the references of retrieved studies manually. Odds ratios (OR) and 95% confidence intervals (95% CI) were calculated to evaluate the strength of these associations. Simultaneously, publication bias was estimated by funnel plot and Begg’s test with Stata 11 software.

Results

We observed a significant association between CYP1B1 L432V polymorphism and urinary cancers. The overall OR (95% CI) of CC versus CG was 0.937 (0.881-0.996), the overall OR (95% CI) of CC versus CG + GG was 0.942 (0.890-0.997). Furthermore, we identified reduced risk for CC versus other phenotypes in both prostate and overall urinary cancers, when studies were limited to Caucasian or Asian patients.

Conclusions

This meta-analysis suggests that the CYP1B1 L432V polymorphism is associated with urinary cancer risk.

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/3108829721231527 webcite

Keywords:
CYP1B1; Polymorphism; Urinary cancer; Susceptibility; Meta-analysis