Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab
1 Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima-shi, Fukushima 960-1295, Japan
2 Department of Radiology, Fukushima Medical University School of Medicine, Fukushima, Japan
3 Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan
4 Fukushima Pathology Laboratory, Fukushima, Japan
Diagnostic Pathology 2014, 9:111 doi:10.1186/1746-1596-9-111Published: 7 June 2014
We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and 18F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells.
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