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Radiological and pathological characteristics of giant cell tumor of bone treated with denosumab

Michiyuki Hakozaki1*, Takahiro Tajino1, Hitoshi Yamada1, Osamu Hasegawa2, Kazuhiro Tasaki3, Kazuo Watanabe4 and Shinichi Konno1

Author Affiliations

1 Department of Orthopaedic Surgery, Fukushima Medical University School of Medicine, 1 Hikarigaoka, Fukushima-shi, Fukushima 960-1295, Japan

2 Department of Radiology, Fukushima Medical University School of Medicine, Fukushima, Japan

3 Department of Pathology and Diagnostic Pathology, Fukushima Medical University School of Medicine, Fukushima, Japan

4 Fukushima Pathology Laboratory, Fukushima, Japan

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Diagnostic Pathology 2014, 9:111  doi:10.1186/1746-1596-9-111

Published: 7 June 2014


We describe a case of giant cell tumor of the proximal tibia with skip bone metastases of the ipsilateral femur in a 20-year-old man. After the neoadjuvant treatment with denosumab, plain radiographs and computed tomography showed marked osteosclerosis and sclerotic rim formation, and 18F-FDG PET/CT showed a decreased standardized uptake value, whereas magnetic resonance imaging showed diffuse enhancement of the tumor, nearly the same findings as those at pretreatment. Pathological findings of the surgical specimen after the denosumab treatment showed benign fibrous histiocytoma-like features with complete disappearance of both mononuclear stromal cells and multinuclear osteoclast-like giant cells.

The virtual slide(s) for this article can be found here: webcite

Giant cell tumor of bone; Denosumab; Neoadjuvant chemotherapy; Receptor activator of nuclear factor-κB ligand (RANKL); Plain radiograph; MRI; 18F-FDG PET/CT; Benign fibrous histiocytoma