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Giant pelvic angiomyofibroblastoma: case report and literature review

Ping Qiu1, Zhe Wang2, Yao Li1* and Guangbin Cui3*

Author Affiliations

1 Department of Endocrinology, The First Affiliated Hospital of Chengdu Medical College, Chengdu, Sichuan 610500, People’s Republic of China

2 Department of Pathology, State Key Laboratory of Cancer Biology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an, Shanxi 710032, People’s Republic of China

3 Department of Radiology, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shanxi 710038, People’s Republic of China

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Diagnostic Pathology 2014, 9:106  doi:10.1186/1746-1596-9-106

Published: 3 June 2014


Angiomyofibroblastoma (AMF) is a rare, benign, soft-tissue tumor, which predominantly occurs in the vulvovaginal region of middle-aged women. It is clinically important to distinguish an AMF from other stromal cell lesions. Here, we report the case of a 32-year-old woman with a rare, giant pelvic AMF, which showed a benign clinical course. The tumor was located in the cul-de-sac of Douglas. It was well demarcated, hypocellular, edematous and composed of spindle-shaped and oval stromal cells aggregating around thin-walled blood vessels. The tumor cells had abundant eosinophilic cytoplasm, and expressed estrogen receptors, progesterone receptors and desmin. Mitotic figures were absent. It is important to distinguish AMFs from aggressive angiomyxomas because both occur at similar sites but show different clinical behaviors. Most AMFs and aggressive angiomyxomas have the same immunohistochemical phenotype. The well-circumscribed borders of AMF are the most important characteristic that distinguish it from aggressive angiomyxomas. AMFs rarely recur after complete surgical excision.

Virtual Slides

The virtual slide(s) for this article can be found here: webcite.

Angiomyofibroblastoma (AMF); Aggressive angiomyxoma (AAM); Pelvis