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An unusual case of Acanthamoeba Polyphaga and Pseudomonas Aeruginosa keratitis

Jiaxu Hong123, Jian Ji1, Jianjiang Xu1*, Wenjun Cao1, Zuguo Liu3 and Xinghuai Sun14

Author Affiliations

1 Department of Ophthalmology and Visual Science, Eye, Ear, Nose, and Throat Hospital, School of Shanghai Medicine, Fudan University, 83 Fenyang Road, Shanghai 200031, China

2 Health Communication Institute, Fudan University, 130 Dongan Road, Shanghai 200032, China

3 Eye Institute of Xiamen University, Fujian 361005, China

4 Myopia Key Laboratory of Ministry of Health, Shanghai, China

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Diagnostic Pathology 2014, 9:105  doi:10.1186/1746-1596-9-105

Published: 3 June 2014


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A 56-year-old woman with a history of disposable soft contact lens wear was referred to our university eye center for a corneal ulcer. Based on the microbial culture, the initial diagnosis was bacterial keratitis, which was unresponsive to topical fortified antibiotics. The patient was then examined using in vivo confocal microscopy, which revealed Acanthamoeba infection. This case emphasizes the need to suspect Acanthamoeba infection in soft contact lens wearers who present with progressive ulcerative keratitis or progressively worsening corneal ulcers that are not responsive to the usual antimicrobial therapy. It is also important to consider the possibility of a coinfection with bacterial and Acanthamoeba species.

Contact lens; Acanthamoeba species; Pseudomonas aeruginosa