Table 1

Differences in membrane-stainings according to FISH-positivity.

FISH -

FISH +

FISH -

FISH +

FISH -

FISH +

FISH -

FISH +

FISH -

FISH +

FISH -

FISH +


p=

0.07097

    0.01782

0.05574

    0.00031

    0.00166

    0.00486


HER2 2+ % RATIO

HER2 2+ % RATIO

HER2 3+ % RATIO

HER2 3+ % RATIO

H-Score

H-Score

L0_CMA:1+

L0_CMA:1+

L0_CMA:2+

L0_CMA:2+

L0_CMA:3+

L0_CMA:3+


Average

0.08386

0.152766

0.012607

0.04071

61.25344

88.80895

7315.882

25794.81

1317.471

12464.48

184.7127

2866.724

SD

0.107272

0.135455

0.024028

0.047413

42.95535

48.74765

4898.122

21455.78

1796.785

15429.72

365.2118

4210.592

Min.

0

0

0

0

3.007519

9.550562

207.6841

1472.817

0

0

0

0

Max.

0.28777

0.408517

0.098592

0.162461

136.6906

170.5047

19422.9

67658.91

5221.888

46501.73

1549.739

11813.45


MembraneQuant calculates intensity scores for each cell within an annotation and additional proportional score. Significant difference is highlighted underlining; italics indicates strong tendency. FISH+ cases had significantly higher HER2-IHC3+ proportional score, while IHER2-IHC2+ proportional score and H-score had a tendency of higher occurrence in the FISH+ cases. In our set, the most significant differences (underlined) were found between FISH-positive and negative cases in the label-area of different IHC-intensity classes.

Micsik et al. Diagnostic Pathology 2013 8(Suppl 1):S14   doi:10.1186/1746-1596-8-S1-S14

Open Data