Table 2

Meta-analysis on the association between MTHFR Ala222Val polymorphism and bladder cancer risk
Variables Study number Sample size Test of heterogeneity Test of Association
case control Ph I2 OR(95% CL) P
Ala/Ala vs Val/Val
Total 15 3570 3926 0.04 44.3% 0.96 (0.76 1.21) 0.73
Ethnicity
Caucasian 5 1342 1466 0.70 0.0% 1.07 (0.83 1.38) 0.59
Asian 5 1804 1990 0.00 74.3% 0.68 (0.41 1.12) 0.13
African 4 407 453 0.91 0.0% 1.50 (0.91 2.45) 0.11
Mixed population 1 17 17
Source of control
HB 7 1075 1273 0.07 49.3% 0.90 (0.58 1.39) 0.62
PB 8 2495 2653 0.14 37.5% 1.20 (0.79 1.31) 0.88
Ala/Ala vs Ala/Val
Total 15 3570 3926 0.05 41.3% 0.92 (0.80 1.06) 0.24
Ethnicity
Caucasian 5 1342 1466 0.05 58.9% 1.05 (0.81 1.37) 0.70
Asian 5 1804 1990 0.15 40.4% 0.86 (0.69 1.06) 0.15
African 4 407 453 0.26 25.9% 0.80 (0.56 1.13) 0.20
Mixed population 1 17 17 4.92 (0.49 49.61) 0.18
Source of control
HB 7 1075 1273 0.40 3.7% 0.82 (0.68 0.98) 0.03
PB 8 2495 2653 0.04 51.5% 1.01 (0.82 1.23) 0.94
Ala/Val vs Val/Val
Total 15 3570 3926 0.22 21.5% 1.02 (0.85 1.23) 0.81
Ethnicity
Caucasian 5 1342 1466 0.69 0.0% 1.07 (0.83 1.37) 0.60
Asian 5 1804 1990 0.18 36.0% 0.84 (0.63 1.12) 0.24
African 4 407 453 0.86 0.0% 1.86 (1.14 3.03) 0.01
Mixed population 1 17 17
Source of control
HB 7 1075 1273 0.14 38.6% 1.08 (0.73 1.59) 0.71
PB 8 2495 2653 0.35 10.7% 1.03 (0.85 1.25) 0.76
Dominant model
Total 15 3570 3926 0.12 32.3% 1.00 (0.87 1.15) 0.98
Ethnicity
Caucasian 5 1342 1466 0.86 0.0% 1.07 (0.84 1.35) 0.58
Asian 5 1804 1990 0.03 63.4% 0.77 (0.52 1.12) 0.17
African 4 407 453 0.94 0.0% 1.68 (1.05 2.69) 0.03
Mixed population 1 17 17
Source of control
HB 7 1075 1273 0.09 46.0% 1.00 (0.67 1.49) 0.99
PB 8 2495 2653 0.29 18.4% 1.03 (0.84 1.25) 0.80
Recessive model
Total 15 3570 3926 0.02 49.1% 0.92 (0.79 1.07) 0.28
Ethnicity
Caucasian 5 1342 1466 0.07 54.4% 1.06 (0.83 1.34) 0.66
Asian 5 1804 1990 0.02 67.0% 0.79 (0.60 1.04) 0.09
African 4 407 453 0.33 12.9% 0.90 (0.67 1.21) 0.49
Mixed population 1 17 17 4.92 (0.49 49.61) 0.18
Source of control
HB 7 1075 1273 0.20 29.8% 0.92 (0.66 1.01) 0.06
PB 8 2495 2653 0.04 53.5% 1.01 (0.83 1.23) 0.90
Ala-allele vs Val-allele
Total 15 3570 3926 0.01 50.5% 0.96 (0.86 1.07) 0.43
Ethnicity
Caucasian 5 1342 1466 0.26 23.8% 1.03 (0.90 1.18) 0.66
Asian 5 1804 1990 0.00 76.5% 0.81 (0.65 1.03) 0.08
African 4 407 453 0.65 0.0% 1.05 (0.86 1.29) 0.63
Mixed population 1 17 17 4.40 (0.47 41.60) 0.20
Source of control
HB 7 1075 1273 0.07 48.0% 0.89 (0.74 1.06) 0.19
PB 8 2495 2653 0.07 47.3% 1.01 (0.89 1.15) 0.89

HB Hospital-Based Study, PB Population-Based Study, Ph P value of heterogeneit.

Xu et al.

Xu et al. Diagnostic Pathology 2013 8:95   doi:10.1186/1746-1596-8-95

Open Data