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Open Access Case Report

An extraordinary T/NK lymphoma, nasal type, occurring primarily in the prostate gland with unusual CD30 positivity: case report and review of the literature

QingPing Jiang1, Shaoyan Liu1, Juan Peng1, Hanzhen Xiong1, ZhongTang Xiong1, Yuexin Yang1, Xuexian Tan1 and Xingcheng Gao2*

Author affiliations

1 Department of Pathology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China

2 Department of Urology, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou 510150, China

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Citation and License

Diagnostic Pathology 2013, 8:94  doi:10.1186/1746-1596-8-94

Published: 17 June 2013

Abstract

Extranodal NK/T cell lymphoma(NKTCL), nasal type, occurring primarily in the prostate gland, is extremely rare. We present a case of primarily prostatic NKTCL in a 59-year-old man suffering from dysuria. Histological examinations revealed that diffused, large-sized, pleomorphic lymphocytes were arranged in an angiocentric distribution with large areas of geographic necroses. Additionally, the prostatic glands were diffusely infiltrated by heteromorphous lymphocytes forming lymphoepithelial lesions. The tumor cells were strongly expressed CD3ϵ, CD56, TIA-1, granzyme B and EBV-encoded RNAs. And interestingly, the lymphoid cells were also strongly immunoreactive with CD30. A rearrangement study showed T-cell receptor γ-chain gene rearrangement with monoclonal appearance. Though postoperative combination of chemotherapy was given, the patient died four months later. Our observation and other literatures indicate that extremely rare NKTCLs unusually express CD30. TCR gene rearrangement existed in some NKTCL, suggesting that a subset of NKTCL may be a mixed NK/T-cell differentiation.

Virtual slides

The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/vs/9671878568932824 webcite.

Keywords:
Prostate; Extranodal NK/T cell lymphoma; Nasal type; CD30; T-cell receptor genes; Lymphoepithelial lesion