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Solitary myofibroma of the sigmoid colon: case report and review of the literature

Mi-Jung Kim1, Suk Hee Lee1, Eui Gon Youk2, Sojin Lee3, Joon Hyuk Choi4 and Kyung-Ja Cho5*

Author Affiliations

1 Departments of Pathology, Daehang Hospital, Seoul, Korea

2 Department of Surgery, Daehang Hospital, Seoul, Korea

3 Department of Radiology, Daehang Hospital, Seoul, Korea

4 Department of Pathology, Yeungnam University College of Medicine, Daegu, Korea

5 Department of Pathology, University of Ulsan College of Medicine, Asan Medical Center, 388-1 Pungnap-dong, Seoul, Songpa-gu 138-736, Korea

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Diagnostic Pathology 2013, 8:90  doi:10.1186/1746-1596-8-90

Published: 6 June 2013


A 58-year-old woman presented with a solitary myofibroma that arose in the sigmoid colon. Computed tomography revealed a highly enhanced intramural mass (1.3-cm maximum diameter) in the proximal sigmoid colon. Histologically, the tumor exhibited a biphasic growth pattern, which comprised haphazardly arranged, interwoven fascicles of plump, myoid-appearing spindle cells with elongated nuclei and abundant eosinophilic cytoplasm, and more cellular areas of primitive-appearing polygonal cells that were arranged in a hemangiopericytomatous pattern. The tumor cells were positive for smooth muscle actin (SMA), and negative for desmin, h-caldesmon, CD34, cytokeratin, S100 protein, and CD117. The Ki-67 labeling index was not high (up to 7%). Based on these histologic and immunohistochemical features, our patient was diagnosed with a myofibroma of the sigmoid colon. The presence of solitary myofibroma in the intestine of an adult requires attention to avoid misdiagnosis as a more aggressive mesenchymal tumor.

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Myofibroma; Solitary; Sigmoid colon; Adult