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Ulnar malignant peripheral nerve sheath tumour diagnosis in a mixed-breed dog as a model to study human: histologic, immunohistochemical, and clinicopathologic study

Abbas Tavasoly1, Javad Javanbakht1*, Fariba Khaki1, Ehsan Hosseini2, Alimohammad Bahrami2, Mehdi Aghamohammad Hassan3 and Mohammadmehdi Mirabad3

Author Affiliations

1 Department of Pathology, Faculty of Veterinary Medicines, Tehran University, Tehran, Iran

2 Paraveterinary Faculty of Ilam, University of Ilam, Ilam, Iran

3 Department of Clinical Science, Faculty of Veterinary Medicine, Tehran University, Tehran, Iran

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Diagnostic Pathology 2013, 8:86  doi:10.1186/1746-1596-8-86

Published: 20 May 2013


Canine Malignant Peripheral Nerve Sheath Tumors (MPNSTs) are uncommonly reported in the ulnar, since they are underestimated relative to the more common spindle cell tumours of soft tissue. In dogs, MPNST accounts for 27% of nervous system tumours. In man, MPNST represents 5-10% of all soft tissue sarcomas and is often associated with neurofibromatosis type 1 (NF-1).An 8-year-old, 9 kg, female mixed-breed dog with a subcutaneous mass on the upper right side of the ulnar region was presented to the small animal research and teaching hospital of Tehran University. The dog was anorexic with general weakness. The mass (7 × 4 cm) was removed surgically and processed routinely. Microscopically, the mass was composed of highly cellular areas with a homogeneous population of round or spindle cells, high cellular pleomorphism, high mitotic index and various morphologic patterns. Furthermore, spindle cells arranged in densely or loosely sweeping fascicles, interlacing whorls, or storiform patterns together with wavy cytoplasm, nuclear palisades, and round cells were arranged in sheets or cords with a meshwork of intratumoral nerve fibers. In addition, in this case the presence of neoplastic cells within the blood vessels was observed. Immunohistochemically, tumor was positive for vimentin and S-100 protein. The histopathologic features coupled with the S-100 and vimentin immunoreactivity led to a diagnosis of malignant neurofibroma.

To the best of our knowledge, primary ulnar MPNST has not been reported in animals. This is the first documentation of an ulnar malignant peripheral nerve sheath tumour in a dog.

Virtual slides

The virtual slide(s) for this article can be found here: webcite

Dog; Pathology; Immunohistochemistry; Tumor; Markers