Email updates

Keep up to date with the latest news and content from Diagnostic Pathology and BioMed Central.

Open Access Highly Accessed Open Badges Case Report

Transformation of a post-cesarean section placental site nodule into a coexisting epithelioid trophoblastic tumor and placental site trophoblastic tumor: a case report

Bo-Jung Chen1, Chien-Jui Cheng12 and Wei-Yu Chen23*

Author affiliations

1 Deparment of Pathology, Taipei Medical University Hospital, Taipei, Taiwan

2 Department of Pathology, School of Medicine, College of Medicine, Taipei Medical University, 250 Wu-Hsing St, Taipei 11031, Taiwan

3 Department of Pathology, Wan Fang Hospital, Taipei Medical University, Taipei, Taiwan

For all author emails, please log on.

Citation and License

Diagnostic Pathology 2013, 8:85  doi:10.1186/1746-1596-8-85

Published: 20 May 2013



Placental site nodules (PSNs) and epithelioid trophoblastic tumors (ETTs) respectively represent non-neoplastic and neoplastic lesions of chorionic-type intermediate trophoblasts (ITs). Many patients with a PSN have a history of a cesarean section (CS) or therapeutic abortion. Recent evidence shows that a PSN may progress to an ETT. Herein, we describe a coexisting ETT and placental site trophoblastic tumor (PSTT) intimately associated with PSNs in the post-cesarean lower uterine segment of a 41-year-old woman. The patient presented with abnormal vaginal bleeding 1 year after a cesarean delivery for her most recent pregnancy. We speculated that the neoplasms had transformed from PSNs, the formation of which was related to faulty expulsion of the placental tissue or abnormal colonization of chorionic-type ITs during the CS. Neoplastic trophoblastic cells derived from PSNs displayed differentiation plasticity toward chorionic-type ITs and implantation site ITs that were respectively constituted of an ETT and PSTT.

Virtual slides

The virtual slides for this article can be found here: webcite

Placental site nodule; Epithelioid trophoblastic tumor; Placental site trophoblastic tumor; Intermediate trophoblast; Cesarean section