Histopathological examinations in patient with invasive pulmonary mucormycosis presenting reversed halo sigh. (A) The dagger (†) and the asterisk signs (*) are placed on the areas of ground-glass opacity (GGO) and outer rim on computed tomography image, respectively. The area of GGO comprised coagulation necrosis with remaining alveolar septa and air content. The outer rim comprised triplet structure; liquefaction, consolidation, and organization from the inner to the outer layer (Photomicrographs stained with hematoxylin and eosin (HE) double stain and scale bar represents 1000 μm). (B) High-power field of the consolidation, the second layer of the outer rim was constituent with mononuclear cell and multinucleated giant cell filling alveolar space (Photomicrographs stained with HE double stain and scale bar represents 100 μm). (C) High-power field of the liquefaction layer of the outer rim. Necrosis and neutrophil infiltration was observed, whereas no elastic fiber was observed (Photomicrographs stained with HE double stain and scale bar represents 100 μm).
Okubo et al. Diagnostic Pathology 2013 8:82 doi:10.1186/1746-1596-8-82